Distributed neural representations of conditioned threat in the human brain.
Distributed neural representations of conditioned threat in the human brain.
复制标题
人脑中条件威胁的分布式神经表征。
DOI：
10.1038/s41467-024-46508-0
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发表时间：
2024
影响因子：
16.6
通讯作者：
Milad,MohammedR
中科院分区：
文献类型：
--
作者：
Wen,Zhenfu;Pace-Schott,EdwardF;Lazar,SaraW;Rosén,Jörgen;Åhs,Fredrik;Phelps,ElizabethA;LeDoux,JosephE;Milad,MohammedR
对威胁的检测和反应涉及几个神经节点，包括杏仁核、海马体、岛叶皮质和内侧前额叶皮质。最近的主张呼吁整合更分散的神经节点，这些节点处理与威胁相关的感觉和认知方面。用于检测和响应威胁和安全的集成式、灵敏和可重复的分布式神经解码器尚未建立。我们将来自1465名参与者的不同威胁条件反射和负面情绪范式的功能磁共振数据与多变量模式分析相结合，以研究威胁和安全的分布式神经表征。训练有素的解码员敏感而具体地区分多个数据集中的威胁和安全线索。我们进一步证明，许多神经节点在威胁和安全之间动态地转换表示。我们的结果建立了集成神经电路的可重复解码器，将特征良好的“威胁电路”与感觉和认知节点合并，无论实验设计或数据采集参数如何，都能区分威胁和安全。
Detecting and responding to threat engages several neural nodes including the amygdala, hippocampus, insular cortex, and medial prefrontal cortices. Recent propositions call for the integration of more distributed neural nodes that process sensory and cognitive facets related to threat. Integrative, sensitive, and reproducible distributed neural decoders for the detection and response to threat and safety have yet to be established. We combine functional MRI data across varying threat conditioning and negative affect paradigms from 1465 participants with multivariate pattern analysis to investigate distributed neural representations of threat and safety. The trained decoders sensitively and specifically distinguish between threat and safety cues across multiple datasets. We further show that many neural nodes dynamically shift representations between threat and safety. Our results establish reproducible decoders that integrate neural circuits, merging the well-characterized ‘threat circuit’ with sensory and cognitive nodes, discriminating threat from safety regardless of experimental designs or data acquisition parameters.