Microcephaly and macrocephaly in autism
Microcephaly and macrocephaly in autism
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DOI：
10.1023/a:1023036509476
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发表时间：
1999-04-01
影响因子：
3.9
通讯作者：
Frémolle, J
中科院分区：
文献类型：
--
作者：
Fombonne, E;Rogé, B;Frémolle, J
ddData从一系列的126名自闭症儿童年龄2-16岁，并提到自闭症诊断单位在法国西南部进行了检查。在16.7%的样本中观察到大头畸形（头围>第97百分位数），这一比例明显高于预期。大头畸形在老年受试者中更常见，但与性别、发育水平、癫痫或医学疾病的存在或自闭症的严重程度无关。小头畸形（头围<第3百分位数）也显著增加，发现于15.1%的样本中。小头畸形与内科疾病的存在显著相关。结果支持了最近研究的结果，表明自闭症中大头畸形的发生率升高，汇总已发表的数据，估计为20%。有人认为，在低功能自闭症患者中，患有医学疾病的小头畸形的发病率升高，可能导致延迟了少数特发性自闭症患者对珠围增加的认识。
ddData from a series of 126 autistic children ages 2-16 years and referred to an Autism Diagnosis Unit in South-West France were examined. Macrocephaly (head circumference > 97th centile) was observed in 16.7% of the sample, a significantly higher proportion than that expected. Macrocephaly was more frequent among older subjects but was otherwise not associated with gender, developmental level, the presence of epilepsy or of medical disorders, or severity of autistic symptomatology. Microcephaly (head circumference < 3rd centile) was also significantly raised and found in 15.1% of the: sample. Microcephaly was significantly associated with the presence of medical disorders. Results support those from recent studies suggesting a raised rate of macrocephaly in autism which, pooling published data, can be estimated to be 20%. It is argued that the raised incidence of microcephaly among low-functioning autistic subjects with medical disorders might have contributed to delay the recognition of an increased bead circumference among a minority of subjects with idiopathic autism.