THE APPLICABILITY OF THE HYPOTHESIS OF INDEPENDENT ACTION TO FATAL INFECTIONS IN MICE GIVEN SALMONELLA-TYPHIMURIUM BY MOUTH
THE APPLICABILITY OF THE HYPOTHESIS OF INDEPENDENT ACTION TO FATAL INFECTIONS IN MICE GIVEN SALMONELLA-TYPHIMURIUM BY MOUTH
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DOI：
10.1099/00221287-16-2-396
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发表时间：
1957-01-01
期刊：
影响因子：
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通讯作者：
MEYNELL, GG
中科院分区：
文献类型：
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作者：
MEYNELL, GG
小鼠被给予含有相同数量的链霉素敏感（Str-）和链霉素抗性（Str+）变体的混合物。虽然它们的毒性相同，但Str-变种生长得更快.死亡后，检查心脏血液样本。从少于一个LD 50剂量死亡的小鼠的血液中含有Str-、Str+或两种变体的混合物。单独出现Str+变种表明感染是由极少数或可能由单一微生物引发的，因此这些微生物是独立作用的。
Mice were given a mixture containing equal numbers of streptomycin-sensitive (Str-) and streptomycin-resistant (Str+) variants. Although they are equally virulent the Str- varient grows more rapidly. Following death, samples of heart blood were examined. Blood from mice dying from less than one LD50 dose contained Str-, Str+, or a mixture of the two variants. The appearance of the Str+ varient alone suggests that infections were initiated by a very small number or possibly by a single organism, and therefore that the organisms were acting independently.