A central role for the endothelial NADPH oxidase in atherosclerosis
A central role for the endothelial NADPH oxidase in atherosclerosis
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DOI：
10.1016/s0014-5793(00)01397-1
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发表时间：
2000-04-21
期刊：
影响因子：
3.5
通讯作者：
Schmitt, ME
中科院分区：
文献类型：
--
作者：
Meyer, JW;Schmitt, ME
越来越多的证据表明，NADPH 氧化酶在导致动脉粥样硬化发展的几个早期步骤中发挥着关键作用。这些作用似乎是通过 O-2(-) 作为小第二信使分子的能力以及 O-2(-) 对低密度脂蛋白的潜在氧化来实现的。我们描述了动脉粥样硬化发生和发展的模型，该模型表明靶向抑制 NADPH 氧化酶是预防和治疗这种疾病的有力部位。 (C) 2000 年欧洲生化学会联合会。
An increasing body of evidence has demonstrated that NADPH oxidase plays a critical role in several early steps leading toward the development of atherosclerosis, These effects appear to be carried out by both the ability of O-2(-) to act as a small second messenger molecule, and potentially the oxidation of low density lipoprotein by O-2(-). We describe a model for the initiation and development of atherosclerosis that suggests targeted inhibition of NADPH oxidase as a powerful site for prevention and treatment of this disease. (C) 2000 Federation of European Biochemical Societies.