Early initiation of low-dose aspirin for reduction in preeclampsia risk in high-risk women: a secondary analysis of the MFMU High-Risk Aspirin Study
Early initiation of low-dose aspirin for reduction in preeclampsia risk in high-risk women: a secondary analysis of the MFMU High-Risk Aspirin Study
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DOI：
10.1038/jp.2014.214
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发表时间：
2015-05-01
影响因子：
2.9
通讯作者：
Heyborne, K. D.
中科院分区：
文献类型：
--
作者：
Moore, G. S.;Allshouse, A. A.;Heyborne, K. D.
目的：早期应用小剂量阿司匹林(LDA)可降低子痫前期的风险。研究设计：对母胎医学单位高危阿司匹林研究的二次分析，包括入选17w0d的妇女，随机分为LDA(60毫克/天(-1))或安慰剂合并慢性高血压(CHTN，n=186)、糖尿病(n=191)或先兆子痫(n=146)。主要结局是妊娠期任何时候的先兆子痫，次要结局是早期先兆子痫(=34W)、小于胎龄儿(SGA；新生儿出生体重为10%)和复合型(早期先兆子痫或SGA)。结果：治疗组之间的基线特征相似。阿司匹林与晚发性先兆子痫的发生率和Gt；=34W(17.36%vs24.42%，P=0.047)有关，而慢性HTN妇女的晚发性子痫前期发生率降低了41%(18.28%vs31.18%，P=0.041)。两组结果无其他显著差异。结论：阿司匹林起效
OBJECTIVE: Early initiation of low-dose aspirin (LDA) may reduce preeclampsia risk. We sought to determine whether LDA was beneficial when initiated < 17w0d, within a trial of high-risk women enrolled < 26w0d.STUDY DESIGN: Secondary analysis of the Maternal-Fetal Medicine Units High-Risk Aspirin study, including women enrolled < 17w0d, randomized to LDA (60 mg day(-1)) or placebo with chronic hypertension (CHTN, n = 186), diabetes (n = 191) or prior preeclampsia (n = 146). The primary outcome was preeclampsia at any time in pregnancy, secondary outcomes were early preeclampsia (= 34w), small for gestational age (SGA; neonatal birthweight < 10th %) and composite (early preeclampsia or SGA). Outcomes were compared by exact chi(2)-tests.RESULTS: Baseline characteristics were similar between treatment groups. Aspirin was associated with a lower rate of late-onset preeclampsia >= 34w (17.36% vs 24.42%, P = 0.047), with a 41% reduction in women with CHTN (18.28% vs 31.18%, P = 0.041). There were no other significant differences in the outcome.CONCLUSION: Aspirin initiated