Alzheimer's disease and disseminated mycoses
Alzheimer's disease and disseminated mycoses
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DOI：
10.1007/s10096-013-2045-z
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发表时间：
2014-07-01
影响因子：
4.5
通讯作者：
Carrasco, L.
中科院分区：
文献类型：
--
作者：
Alonso, R.;Pisa, D.;Carrasco, L.
阿尔茨海默病（AD）的特征在于脑中存在淀粉样蛋白斑块和神经元缠结，其引起神经元细胞死亡、血管功能障碍和炎症过程。在目前的工作中，我们已经分析了AD患者真菌感染的存在。已在血清中进行了许多测试，包括检测针对几种酵母菌和真菌蛋白的抗体，以及真菌（1，3）-β-葡聚糖的存在。该分析的结果表明，在大多数AD患者中存在播散性真菌感染。值得注意的是，一些AD患者外周血中含有高水平的真菌多糖，这反映了这些患者中发生了播散性真菌感染。总之，这些结果表明AD患者血清中存在播散性真菌病。据我们所知，这些发现代表了AD患者血液样本中可检测到真菌感染的第一个证据。这可能是一个危险因素或可能有助于AD的病因的可能性进行了讨论。
Alzheimer's disease (AD) is characterized by the presence in the brain of amyloid plaques and neurofibrillary tangles that provoke neuronal cell death, vascular dysfunction and inflammatory processes. In the present work, we have analyzed the existence of fungal infection in AD patients. A number of tests have been carried out in blood serum, including the detection of antibodies against several yeast species and fungal proteins, and also the presence of fungal (1,3)-beta-glucan. Results from this analysis indicate that there is disseminated fungal infection in the majority of AD patients tested. Of interest, several AD patients contain high levels of fungal polysaccharides in peripheral blood, reflecting that disseminated fungal infection occurs in these patients. Together, these results suggest the presence of disseminated mycoses in blood serum from AD patients. To our knowledge these findings represent the first evidence that fungal infection is detectable in blood samples in AD patients. The possibility that this may represent a risk factor or may contribute to the etiological cause of AD is discussed.