Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors
Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors
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DOI：
10.1093/jnci/djz136
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发表时间：
2019-12-01
影响因子：
10.3
通讯作者：
Hurria, Arti
中科院分区：
文献类型：
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作者：
Guida, Jennifer L.;Ahles, Tim A.;Hurria, Arti
观察数据表明，一些癌症幸存者比从未诊断出患有癌症或暴露于全身或靶向癌症治疗的类似年龄的个体更早和/或负担更大地发展慢性疾病，如虚弱，肌肉减少症，心脏功能障碍和轻度认知障碍。总的来说，癌症幸存者经历的癌症和治疗相关的身体、认知和心理社会晚期和长期发病率被假设为代表加速或加重的衰老轨迹。然而，概念，测量和方法学的挑战限制了识别，预测和减轻癌症和癌症治疗的衰老相关后果的努力。2018年7月，美国国家癌症研究所召集了基础、临床和转化科学专家，成立了一个名为“测量衰老和识别癌症幸存者的衰老表型”的智库。“通过讨论，确定了若干研究和资源需求，包括纵向研究，以检查衰老轨迹，包括癌症治疗之前、期间和之后的详细数据;机制研究，以阐明导致癌症幸存者出现衰老表型的途径;长期临床监测，以监测幸存者的后期效应;以及整合多个数据源的工具，以了解癌症及其治疗如何促进衰老过程。满足这些需求将有助于扩大证据基础，并为优化癌症幸存者健康老龄化的策略提供信息。
Observational data have shown that some cancer survivors develop chronic conditions like frailty, sarcopenia, cardiac dysfunction, and mild cognitive impairment earlier and/or at a greater burden than similarly aged individuals never diagnosed with cancer or exposed to systemic or targeted cancer therapies. In aggregate, cancer- and treatment-related physical, cognitive, and psychosocial late- and long-term morbidities experienced by cancer survivors are hypothesized to represent accelerated or accentuated aging trajectories. However, conceptual, measurement, and methodological challenges have constrained efforts to identify, predict, and mitigate aging-related consequences of cancer and cancer treatment. In July 2018, the National Cancer Institute convened basic, clinical, and translational science experts for a think tank titled "Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors." Through the resulting deliberations, several research and resource needs were identified, including longitudinal studies to examine aging trajectories that include detailed data from before, during, and after cancer treatment; mechanistic studies to elucidate the pathways that lead to the emergence of aging phenotypes in cancer survivors; long-termclinical surveillance to monitor survivors for late-emerging effects; and tools to integrate multiple data sources to inform understanding of how cancer and its therapies contribute to the aging process. Addressing these needs will help expand the evidence base and inform strategies to optimize healthy aging of cancer survivors.