Mitochondrial dynamics and inter-mitochondrial communication in the heart
Mitochondrial dynamics and inter-mitochondrial communication in the heart
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心脏中的线粒体动力学和线粒体间通讯
DOI：
10.1016/j.abb.2019.01.017
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发表时间：
2019-03-15
影响因子：
3.9
通讯作者：
Zheng, Ming
中科院分区：
文献类型：
--
作者：
Cao, Yang-Po;Zheng, Ming
线粒体是大多数类型细胞中高度动态的细胞器，不断改变形态并形成动态连续的网络。线粒体动力学缺陷与包括神经退行性疾病和心血管疾病在内的各种人类疾病相关。在心脏中，线粒体在肌丝之间刚性地组织成晶体状的晶格模式，明显受限的线粒体运动提出了线粒体是否动态地相互通信的问题。大量证据表明，心脏疾病中线粒体形态异常，线粒体动力学相关蛋白的缺失导致心脏功能障碍，提示线粒体动力学在调节心脏功能中起重要作用。本文将综述心脏线粒体动力学的研究进展，重点介绍成年心肌细胞线粒体间直接通讯的最新发现，并讨论其可能的调控机制。
Mitochondria are organelles highly dynamic in most types of cells, constantly changing morphology and forming dynamically continuous networks. Defects of mitochondrial dynamics are associated with various human diseases including neurodegenerative diseases and cardiovascular diseases. In the heart, mitochondria are rigidly organized between myofilaments into a crystal-like lattice pattern, the apparently limited mitochondrial movement raises the question of whether mitochondria communicate with each other dynamically. A large body of evidence reveals abnormal mitochondrial morphology in cardiac diseases and that deficiencies of mitochondrial dynamic related proteins lead to cardiac dysfunctions, indicating an essential role of mitochondrial dynamics in regulating the cardiac function. Here we will review mitochondrial dynamics in the heart with the focus on recent findings of the direct inter-mitochondrial communication in adult cardiomyocytes, and will discuss the possible regulating mechanisms.