Understanding the Impacts of Surface Compositions on the In-Vitro Dissolution and Aerosolization of Co-Spray-Dried Composite Powder Formulations for Inhalation.
Understanding the Impacts of Surface Compositions on the In-Vitro Dissolution and Aerosolization of Co-Spray-Dried Composite Powder Formulations for Inhalation.
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DOI：
10.1007/s11095-018-2527-x
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发表时间：
2018-11-07
影响因子：
3.7
通讯作者：
Zhou QT
中科院分区：
文献类型：
--
作者：
Mangal S;Xu R;Park H;Zemlyanov D;Shetty N;Lin YW;Morton D;Chan HK;Li J;Zhou QT
Dissolution behavior of dry powder inhaler (DPI) antibiotic formulations in the airways may affect their efficacy especially for poorly-soluble antibiotics such as azithromycin. The main objective of this study was to understand the effects of surface composition on the dissolution of spray dried azithromycin powders by itself and in combination with colistin. Composite formulations of azithromycin (a poorly water-soluble molecule) and colistin (a water-soluble molecule) were produced by spray drying. The resultant formulations were characterized for particle size, morphology, surface composition, solid-state properties, solubility and dissolution. The results demonstrate that surfaces composition has critical impacts on the dissolution of composite formulations. Colistin was shown to increase the solubility of azithromycin. For composite formulations with no surface colistin, azithromycin released at a similar dissolution rate as the spray-dried azithromycin alone. An increase in surface colistin concentration was shown to accelerate the dissolution of azithromycin. The dissolution of colistin from the composite formulations was significantly slower than the spray-dried pure colistin. In addition, FTIR spectrum showed intermolecular interactions between azithromycin and colistin in the composite formulations, which could contribute to the enhanced solubility and dissolution of azithromycin. Our study provides fundamental understanding of the effects of surface concentration of colistin on azithromycin dissolution of co-spray-dried composite powder formulations.
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影响因子：
5.2
作者：
Favre-Bonté, S;Köhler, T;Van Delden, C
通讯作者：
Van Delden, C
影响因子：
3.7
作者：
Chew, NYK;Tang, P;Raper, JA
通讯作者：
Raper, JA
影响因子：
3
作者：
Kanaze, F. I.;Kokkalou, E.;Bikiaris, D.
通讯作者：
Bikiaris, D.
影响因子：
4.9
作者：
Bae S;Kim MC;Park SJ;Kim HS;Sung H;Kim MN;Kim SH;Lee SO;Choi SH;Woo JH;Kim YS;Chong YP
通讯作者：
Chong YP
影响因子：
3.3
作者：
Jensen, Katrine Tarp;Blaabjerg, Lasse Ingerslev;Lobmann, Korbinian
通讯作者：
Lobmann, Korbinian