Familial and ethnic risk in inflammatory bowel disease.
Familial and ethnic risk in inflammatory bowel disease.
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DOI：
10.20524/aog.2017.0208
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发表时间：
2018-01
影响因子：
2.2
通讯作者：
Torres J
中科院分区：
文献类型：
--
作者：
Santos MPC;Gomes C;Torres J
炎症性肠病（IBD）的家族聚集性已经建立了几十年，反映了共同的遗传和环境易感性。阳性家族史仍然是IBD发展的最强可识别风险因素，约8-12%的IBD患者报告。克罗恩病比溃疡性结肠炎更常见的家族性。受影响先证者的一级亲属患IBD的风险增加4至8倍。双胞胎和患有IBD的夫妇所生子女的风险也显著较高;已描述了受影响家庭成员数量的累积效应，其中有三个或更多受影响成员的家庭的发病率最高。在此，我们回顾了有关家族性IBD的现有证据，并简要讨论了IBD在不同种族和民族中的变化，希望提供有用的更新和实用指南，可以为临床医生提供咨询指导。
Familial aggregation in inflammatory bowel disease (IBD) has been established for several decades, reflecting shared genetic and environmental susceptibility. A positive family history remains the strongest recognizable risk factor for the development of IBD and is reported in around 8-12% of IBD patients. Crohn’s disease shows a more frequent familial pattern than ulcerative colitis. The risk of developing IBD in first-degree relatives of an affected proband is increased 4- to 8-fold. The risk for twins and children born from couples who both have IBD is also substantially higher; a cumulative effect of the number of family members affected has been described, with the highest incidence being described for families with three or more affected members. Herein, we review the available evidence regarding familial IBD, and briefly discuss the variation of IBD across different races and ethnicities, hoping to provide a useful update and a practical guide that can serve clinicians as a guide for counseling.