Effects of withholding food for 0-72 h on mating, pregnancy rate and pituitary function in female rats.
Effects of withholding food for 0-72 h on mating, pregnancy rate and pituitary function in female rats.
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0-72小时禁食对雌性大鼠交配、妊娠率和垂体功能的影响。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
J. Saunders
中科院分区：
文献类型：
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作者：
T. Mcclure;J. Saunders
在发情周期的不同阶段，雌性大鼠禁食0-72小时。在发情前一天 12:00 停止进食 24 小时，使交配率从 61% 降低至 25%（P 小于 0.05），但交配大鼠的妊娠率没有降低。发情当日18:00开始禁食24小时，受孕率从82%降低到18%（P小于0.05），且不影响交配率；发情当日12:00开始禁食48小时，受孕率从82%降低到25%（P小于0.05）。在促发情当天的 17:00 停止进食 23 小时，可以防止通常在这一天 17:00 出现的 LH 和催乳素激增。这些治疗对腺垂体响应 GnRH 注射而释放 LH 的能力没有明显影响。当切除卵巢的雌性大鼠禁食0-72小时并注射两次雌二醇二苯甲酸酯以测试下丘脑通过刺激LH释放对血浆雌二醇浓度增加做出反应的能力时，禁食24小时减少，禁食72小时完全阻止LH释放。
Food was withheld from female rats for 0-72 h at various stages of the oestrous cycle. Withholding food for periods of 24 h ending at 12:00 h on the day of pro-oestrus reduced the mating rate from 61 to 25% (P less than 0.05) but not the pregnancy rate of those rats that mated. Fasting for 24 h ending at 18:00 h on the day of pro-oestrus reduced the pregnancy rate from 82 to 18% (P less than 0.05) without affecting the mating rate and a 48-h fast starting at 12:00 h on the day of pro-oestrus reduced the pregnancy rate from 82 to 25% (P less than 0.05). Withholding food for 23 h ending at 17:00 h on the day of pro-oestrus prevented the LH and prolactin surges normally present at 17:00 h on this day. The treatments had no apparent effect on the ability of the adenohypophysis to release LH in response to injections of GnRH. When ovariectomized female rats fasted for 0-72 h and given 2 injections of oestradiol dibenzoate to test the ability of the hypothalamus to respond to an increasing plasma oestradiol concentration by stimulating the release of LH, a fast for 24 h reduced and a fast for 72 h completely prevented LH release.