ON THE NEUROCHEMICAL BASIS OF SELF-STIMULATION WITH MIDBRAIN RAPHE ELECTRODE PLACEMENTS
ON THE NEUROCHEMICAL BASIS OF SELF-STIMULATION WITH MIDBRAIN RAPHE ELECTRODE PLACEMENTS
复制标题
DOI：
10.1016/0091-3057(80)90275-0
复制
发表时间：
1980-01-01
影响因子：
3.6
通讯作者：
DEAKIN, JFW
中科院分区：
文献类型：
--
作者：
DEAKIN, JFW
用甲麦角林或赛庚啶阻断5-HT（5-羟色胺）受体，用对氯苯丙胺诱导5-HT耗竭，或用脑内微量注射5，7-二羟色胺预先破坏上行5-HT通路，都不能减弱大鼠中缝正中核的电刺激压杆。在一个穿梭箱范例中，大鼠可以启动和终止刺激，p-氯苯丙氨酸没有拮抗刺激的启动。中缝核刺激的奖赏效应不是由多巴胺能机制介导的。α-甲基-p-酪氨酸诱导的儿茶酚胺耗竭对起始行为产生抑制作用，而不损害刺激的终止。中缝核刺激的奖赏成分是由儿茶酚胺介导的。终止（逃避）刺激没有实质性的影响，儿茶酚胺或5-HT耗竭，这表明中缝刺激的厌恶成分可能不介导这些单胺类。
Bar-pressing for electrical stimulation of the median raphe nucleus in rats was not attenuated by 5HT (serotonin) receptor blockade with metergoline or cyproheptadine, by 5HT depletion induced with p-chloroamphetamine or by prior destruction of ascending 5HT pathways with intracerebral microinjections of 5,7-dihydroxytryptamine. In a shuttle box paradigm in which rats could initiate and terminate stimulation, p-chlorophenylalanine did not antagonize initiation of stimulation. The rewarding effects of raphe stimulation are not mediated by serotonergic mechanisms. alpha-Methyl-p-tyrosine induced catecholamine depletion exerted an inhibitory effect on initiation behavior without impairing termination of stimulation. The rewarding component of raphe stimulation is mediated by catecholamines. Termination of (escape from) stimulation was not materially affected by catecholamine or 5HT depletion, suggesting the aversive component of raphe stimulation may not be mediated by these monoamines.