THE ULTRASTRUCTURE OF DESCEMETS MEMBRANE .3. FUCHS DYSTROPHY
THE ULTRASTRUCTURE OF DESCEMETS MEMBRANE .3. FUCHS DYSTROPHY
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DOI：
10.1001/archopht.1982.01030040932013
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发表时间：
1982-01-01
影响因子：
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通讯作者：
CAMPBELL, RJ
中科院分区：
文献类型：
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作者：
BOURNE, WM;JOHNSON, DH;CAMPBELL, RJ
应用透射电镜观察了11只Fuchs营养不良有晶状体眼角膜扣后弹力膜的超微结构。所有角膜均存在与生命早期（20岁之前）异常内皮功能一致的后弹力层脱落。尽管Fuchs营养不良的临床发病相对较晚，但这种疾病的内皮异常在生命早期就存在。在基质和上皮水肿较大的角膜中，异常纤维层较厚，可能表明该层主要在内皮失代偿期间形成。
The ultrastructure of [human] Descemet''s membrane was studied by transmission electron microscopy in corneal buttons removed from 11 phakic eyes with Fuchs'' dystrophy. Abnormalities in Descemet''s membrane consistent with abnormal endothelial function early in life (prior to age 20 yr) were present in all corneas. Despite the relatively late clinical onset of Fuchs'' dystrophy, endothelial abnormalities are present quite early in life in this disease. An abnromal fibrillar layer was thicker in those corneas with greater stromal and epithelial edema, possibly indicating that this layer is formed mainly during periods of endothelial decompensation.