Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma
Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma
复制标题
蛋白磷酸酶镁依赖性 1delta 是肝细胞癌的新型肿瘤标志物和靶点
DOI：
10.1007/s11684-016-0433-3
复制
发表时间：
2016-03-01
影响因子：
8.1
通讯作者：
Chen, Jinfei
中科院分区：
文献类型：
--
作者：
Xu, Zhi;Cao, Chunxiang;Chen, Jinfei
Hepatocellular carcinoma (HCC) is a lethal liver malignancy worldwide. In this study, we reported that protein phosphatase magnesium-dependent 1 delta (PPM1D) was highly expressed in the majority of HCC cases (approximately 59%) and significantly associated with high serum alpha-fetoprotein (AFP) level (P = 0.044). Kaplan- Meier and Cox regression data indicated that PPM1D overexpression was an independent predictor of HCCspecific overall survival (HR, 2.799; 95% CI, 1.346-5.818, P = 0.006). Overexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdown of PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. In addition, PPM1D suppression by small interfering RNA decreased the tumorigenicity of HCC cells in vivo. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target for HCC.
