The Molecular Intersection Between Senescence and Major Depression in the Elderly
The Molecular Intersection Between Senescence and Major Depression in the Elderly
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DOI：
10.1016/j.jagp.2018.07.005
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发表时间：
2018-11-01
影响因子：
7.2
通讯作者：
Diniz, Breno S.
中科院分区：
文献类型：
--
作者：
Diniz, Breno S.
老年人的重度抑郁症或晚年抑郁症（LLD）-是老龄化人口中最常见的精神疾病之一。LLD对健康和福祉有一些负面影响。患有LLD的个体患慢性和持续性抑郁症状的风险较高，并且治疗抵抗率较高。他们也有更高的风险发展为认知障碍，进展为痴呆症和更高的医疗并发症，虚弱和死亡率。将LLD与这些不良健康结果联系起来的机制尚未得到很好的理解。在这篇文章中，我们回顾了LLD患者存在的证据，即，增强的分子和细胞衰老变化，集中在衰老相关的分泌表型（SASP）。然后，我们提出了一个机制模型，联系SASP的更大的风险，在这个人群中的负面健康结果。我们最终提供的证据表明，SASP和细胞衰老一般可以作为减轻LLD这些负面结果的风险的治疗靶点。
Major depressive disorder in the elderly or late-life depression (LLD)-is one of the most common mental illnesses in the aging population. LLD has several negative effects on health and well-being. Individuals with LLD have an elevated risk of chronic and persistent depressive symptoms as well as high rates of treatment resistance. They also have a higher risk of developing cognitive impairment with progression to dementia and higher rates of medical comorbidity, frailty, and mortality. The mechanisms linking LLD to these adverse health outcomes are not well understood. In this article, we review the evidence that individuals with LLD present with, i.e., enhanced molecular and cellular senescent changes, focusing on the senescence-associated secretory phenotype (SASP). We then propose a mechanistic model linking SASP to the greater risk of negative health outcomes in this population. We finally provide evidence that SASP and cellular senescence in general can be a therapeutic target for mitigating the risk of these negative outcomes in LLD.