Effect of an acute bout of aerobic exercise on chemerin levels in obese adults.
Effect of an acute bout of aerobic exercise on chemerin levels in obese adults.
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DOI：
10.1016/j.dsx.2015.04.010
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Keslacy S
中科院分区：
文献类型：
--
作者：
Lloyd JW;Evans KA;Zerfass KM;Holmstrup ME;Kanaley JA;Keslacy S
肥胖者血清chemerin浓度升高，可能在2型糖尿病中起作用。运动改善胰岛素敏感性，这可能与chemerin的变化有关。本研究探讨了急性有氧运动如何影响非糖尿病肥胖成年人的chemerin水平。在两种不同的条件下采集了11名肥胖成年人的血液样本：久坐（SED）和运动（EX; 60- 65%VO2峰值）。在基线、运动后立即和每小时另外2小时抽取样品。ANOVA用于测试条件之间chemerin的差异。未调整的分析显示，条件之间chemerin的总体变化（基线至2小时后）没有差异。在运动后2小时期间，chemerin降低至基线以下12%，而在久坐日的该时间段内，chemerin高于基线增加2.5%（p=0.06，条件之间的后至2小时变化差异）。控制胰岛素抵抗的稳态模型评估（HOMA-IR），EX和SED之间在chemerin从基线到2小时后的变化方面存在显著差异（p=0.02）。分层分析显示，非胰岛素抵抗受试者中chemerin在运动诱导下持续降低，而胰岛素抵抗受试者中chemerin在运动期间升高，然后在运动后降低。肥胖个体的急性运动可能会引起运动后chemerin水平的下降，这种反应可能会因胰岛素抵抗而异。
Serum chemerin concentrations are elevated in obese individuals and may play a role in type 2 diabetes. Exercise improves insulin sensitivity, which may be related to changes in chemerin. This study explored how an acute bout of aerobic exercise affected chemerin levels in non-diabetic obese adults. Blood samples from 11 obese adults were obtained during two separate conditions: sedentary (SED) and exercise (EX; 60-65% VO2peak). Samples were drawn at baseline, immediately following exercise and hourly for an additional 2 hours. ANOVA was used to test for differences in chemerin between conditions. Unadjusted analysis showed no difference in overall change (baseline to 2 hrs post) in chemerin between conditions. During the 2-hr post-exercise period, chemerin decreased to 12% below baseline, compared to a 2.5% increase above baseline during that time period on the sedentary day (p=0.06, difference in post-to-2hr change between conditions). Controlling for homeostatic model assessment of insulin resistance (HOMA-IR), a significant difference existed between EX and SED in the change in chemerin from baseline to 2-hr post (p=0.02). Stratified analyses showed a consistent exercise-induced decrease in chemerin among non-insulin resistant subjects, while chemerin increased during exercise among insulin resistant subjects, and then decreased post-exercise. An acute bout of exercise in obese individuals may elicit a drop in chemerin levels during the post-exercise period, and this response may vary based on insulin resistance.