Emerging roles of lysophosphatidylserine as an immune modulator
Emerging roles of lysophosphatidylserine as an immune modulator
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DOI：
10.1111/imr.13204
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发表时间：
2023-04
影响因子：
8.7
通讯作者：
Shun Yaginuma;Jumpei Omi;Akiharu Uwamizu;J. Aoki
中科院分区：
文献类型：
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作者：
Shun Yaginuma;Jumpei Omi;Akiharu Uwamizu;J. Aoki
除了病原体和抗原的直接激活外，免疫细胞功能还受到其环境中的因素的进一步调节。最近的研究表明，溶血磷脂（LPL）来自膜甘油磷脂是这样的环境因素。它们由各种磷脂酶的作用产生，并通过G蛋白偶联受体型受体积极或消极地调节免疫反应。这些包括溶血磷脂酸、溶血磷脂酰丝氨酸（LysoPS）和溶血磷脂酰肌醇。在这里，我们总结了什么是已知的合成途径，受体和免疫调节功能，这些LPL。特别关注的是LysoPS，这是最近被确定的，和最近的研究结果，他们的免疫调节作用。
In addition to direct activation by pathogens and antigens, immune cell functions are further modulated by factors in their environment. Recent studies have revealed that lysophospholipids (LPL) derived from membrane glycerophospholipids are such environmental factors. They are produced by the action of various phospholipases and modulate immune responses positively or negatively via G‐protein‐coupled receptor‐type receptors. These include lysophosphatidic acid, lysophosphatidylserine (LysoPS), and lysophosphatidylinositol. Here, we summarize what is known about the synthetic pathways, receptors, and immunomodulatory functions of these LPLs. Particular focus is given to LysoPS, which have recently been identified, and recent findings on their immunomodulatory actions are presented.