Tweaking the hinge and caps: Testing a model of the organization of jaws
Tweaking the hinge and caps: Testing a model of the organization of jaws
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DOI：
10.1002/jez.b.21205
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发表时间：
2008-06-15
影响因子：
2.2
通讯作者：
Compagnucci, Claudia
中科院分区：
文献类型：
--
作者：
Depew, Michael J.;Compagnucci, Claudia
从历史上看，对有颚头骨的研究表明，在它们存在的整个过程中，颌骨的特点是高度忠于最初的基本结构设计，然后表现出一系列令人惊讶的终点表型。这两个特点--对包氏结构的忠实和设计的精细--是相互联系和引人注目的，并引出了一些问题，包括：所有的颌骨都是以同样的方式制成的吗？如果不是，又是如何做到的？为了开始解决这些问题，我们在此操作性地将颌定义为两个并列的、铰接的颅骨单元，极性和潜在的模块性是其特征，然后解决它们形成所必需的，包括描绘将正式产生颌的细胞和组织的来源以及告知它们的个体发育的东西（例如，位置信息的来源和指导发展线索解释的因素）。在此之后，我们简要地描述了一个可预测的，可测试的下颌发育模型（“铰链和帽”模型），并提出证据表明，Satb 2+细胞群体在小鼠的下颌原基发育定义了一个发育和进化上显着的下颌模块，如将预测的模型。
Historically, examinations of gnathostome skulls have indicated that for essentially the entirety of their existence, jaws have been characterized by a high degree of fidelity to an initial basic structural design that will then go on to manifest an amazing array of end-point phenotypes. These two traits-bauplan fidelity and elaboration of design-are inter-connected and striking, and beg a number of questions, including: Are all jaws made in the same manner and if not how not? To begin to tackle such questions, we herein operationally define jaws as two appositional, hinged cranial units for which polarity and potential modularity are characteristics, and then address what is necessary for them to form, including delineating both the sources of cells and tissues that will formally yield the jaws as well as what informs their ontogeny (e.g., sources of positional information and factors directing the interpretation of developmental cues). Following on this, we briefly describe a predictive, testable model of jaw development (the "Hinge and Caps" model) and present evidence that the Satb2+cell population in the developing jaw primordia of mice defines a developmentally and evolutionarily significant jaw module such as would be predicted by the model.