Attention Stabilizes Representations in the Human Hippocampus
Attention Stabilizes Representations in the Human Hippocampus
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DOI：
10.1093/cercor/bhv041
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发表时间：
2016-02-01
期刊：
影响因子：
3.7
通讯作者：
Turk-Browne, Nicholas B.
中科院分区：
文献类型：
--
作者：
Aly, Mariam;Turk-Browne, Nicholas B.
注意力和记忆力有着错综复杂的联系，但是注意力如何调节大脑中有助于记忆的区域，比如海马体，还不清楚。我们假设，注意力可能会稳定人类海马体的活动模式，从而导致不同注意力状态下不同但可靠的活动模式。为了验证这一预测，我们使用了高分辨率功能磁共振成像和一个新的“艺术画廊”任务。在每次试验中，参与者观看一个包含绘画的房间，并搜索一系列房间，以寻找同一艺术家的绘画（艺术状态）或具有相同布局的房间（房间状态）。自下而上的刺激在这两项任务中是相同的，从而能够隔离与自上而下的注意力相关的神经效应。多变量分析显示，与不同的注意力状态相比，相同的试验在所有海马子区域中具有更大的模式相似性。这种稳定性是更大的房间比艺术状态，是无关的单变量活动，并在CA 2/CA 3/DG，与行为。因此，注意力诱导人类海马体的表征稳定性，导致不同注意力状态的不同活动模式。海马表征稳定性的调节突出了感觉系统之外的注意力的深远影响。
Attention and memory are intricately linked, but how attention modulates brain areas that subserve memory, such as the hippocampus, is unknown. We hypothesized that attention may stabilize patterns of activity in human hippocampus, resulting in distinct but reliable activity patterns for different attentional states. To test this prediction, we utilized high-resolution functional magnetic resonance imaging and a novel "art gallery" task. On each trial, participants viewed a room containing a painting, and searched a stream of rooms for a painting from the same artist (art state) or a room with the same layout (room state). Bottom-up stimulation was the same in both tasks, enabling the isolation of neural effects related to top-down attention. Multivariate analyses revealed greater pattern similarity in all hippocampal subfields for trials from the same, compared with different, attentional state. This stability was greater for the room than art state, was unrelated to univariate activity, and, in CA2/CA3/DG, was correlated with behavior. Attention therefore induces representational stability in the human hippocampus, resulting in distinct activity patterns for different attentional states. Modulation of hippocampal representational stability highlights the far-reaching influence of attention outside of sensory systems.