Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle
Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle
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DOI：
10.1152/ajpendo.00542.2003
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发表时间：
2004-07-01
影响因子：
5.1
通讯作者：
Febbraio, MA
中科院分区：
文献类型：
--
作者：
Watt, MJ;Holmes, AG;Febbraio, MA
肌内三酰甘油（IMTG）被认为是收缩肌肉的重要代谢底物，尽管这仍然存在争议。为了验证血浆游离脂肪酸（FFA）可用性降低会增加运动过程中IMTG降解的假设，7名活跃男性在60%肺O-2摄取峰值时循环180分钟，分别在没有（CON）或（NA）摄入烟酸的情况下抑制脂肪组织脂解。在运动前、90分钟和180分钟分别获得骨骼肌和脂肪组织活检样本。NA摄取量减少(P
Intramuscular triacylglycerols (IMTG) are proposed to be an important metabolic substrate for contracting muscle, although this remains controversial. To test the hypothesis that reduced plasma free fatty acid (FFA) availability would increase IMTG degradation during exercise, seven active men cycled for 180 min at 60% peak pulmonary O-2 uptake either without (CON) or with (NA) prior ingestion of nicotinic acid to suppress adipose tissue lipolysis. Skeletal muscle and adipose tissue biopsy samples were obtained before and at 90 and 180 min of exercise. NA ingestion decreased (P