Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort.
Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort.
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在动物模型和人类队列中检查氟康唑引起的脱发。
DOI：
10.1128/aac.01384-18
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发表时间：
2019
影响因子：
4.9
通讯作者：
中科院分区：
文献类型：
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作者：
Thompson3rd,GeorgeR;Krois,CharlesR;Affolter,VerenaK;Everett,AngelaD;Varjonen,EKatarina;Sharon,VictoriaR;Singapuri,Anil;Dennis,Michael;McHardy,Ian;Yoo,HongSik;Fedor,DawnM;Wiederhold,NathanP;Aaron,PhyliciaA;Gelli,Angie;
氟康唑引起的脱发是接受长期治疗的患者的一个重要问题。我们在大鼠模型中评估了氟康唑对毛发周期的改变，并研究了潜在的分子机制。未发现血浆和组织中的视黄酸水平是因果关系。人类脱发患者归因于氟康唑也进行了详细的评估，并在我们的小鼠模型和人类队列氟康唑诱导休止期脱发。未来的工作应进一步研究氟康唑诱导脱发的机制。
Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms. Plasma and tissue levels of retinoic acid were not found to be causal. Human patients with alopecia attributed to fluconazole also underwent detailed assessment and in both our murine model and human cohort fluconazole induced telogen effluvium. Future work further examining the mechanism of fluconazole-induced alopecia should be undertaken.