Ultra-localization of Foxp3+ T cells within renal Allografts shows infiltration of tubules mimicking rejection
Ultra-localization of Foxp3+ T cells within renal Allografts shows infiltration of tubules mimicking rejection
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DOI：
10.2353/ajpath.2007.070396
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发表时间：
2007-12-01
影响因子：
6
通讯作者：
Wong, Wilson
中科院分区：
文献类型：
--
作者：
Brown, Kathryn;Moxham, Victoria;Wong, Wilson
通过测量血清肌酐和移植物活检来监测肾移植受者的排斥反应。活检样本根据班夫分类进行评估，该分类指出单核细胞浸润肾小管是急性排斥反应的指标。然而，调节性 T 细胞在整体免疫反应中发挥着至关重要的作用，并且也存在于移植组织中。我们假设肾移植物内单核细胞的浸润并不总是与排斥相关，特别是当这种浸润中很大一部分是调节性 T 细胞时。使用维持生命的小鼠肾移植模型，我们发现单核细胞肾小管浸润可以发生在排斥性和耐受性移植物中。然而，耐受性肾移植物显示出较高且持续水平的Foxp3(+)调节细胞。重要的是，这些细胞的很大一部分是在肾小管内发现的。在移植物功能正常的情况下，这些细胞对肾脏无害，可以说是模仿而不是引起排斥反应。
Kidney transplant recipients are monitored for rejection by measurement of serum creatinine and graft biopsies. Biopsy samples are evaluated according to the Banff classification, which states that infiltration of tubules by mononuclear cells is an indicator of acute rejection. However, regulatory T cells play a crucial role in the overall immune response and are also present within transplanted tissue. We hypothesize that infiltration of mononuclear cells within kidney grafts is not always associated with rejection, especially if a high proportion of this infiltrate is regulatory T cells. Using a life-sustaining mouse kidney transplant model, we found that mononuclear cell tubular infiltration can occur in both rejecting and tolerant grafts. However, tolerant kidney grafts demonstrated a higher and sustained level of Foxp3(+) regulatory cells. Importantly, a significant proportion of these cells were found within tubules. In cases in which graft function was normal, these cells were not harmful to the kidney and could be said to be mimicking, rather than causing, rejection.