New insights into metabolic signaling and cell survival: the role of beta-O-linkage of N-acetylglucosamine.
New insights into metabolic signaling and cell survival: the role of beta-O-linkage of N-acetylglucosamine.
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DOI：
10.1124/jpet.108.143263
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Jones SP
中科院分区：
文献类型：
--
作者：
Ngoh GA;Jones SP
The involvement of glucose in fundamental metabolic pathways represents a core element of biology. Late in the 20th century, a unique glucose-derived signal was discovered, which appeared to be involved in a variety of cellular processes, including mitosis, transcription, insulin signaling, stress responses, and potentially, Alzheimer’s disease, and diabetes. By definition, this glucose-fed signaling system was a posttranslational modification to proteins. However, unlike classical cotranslational N-glycosylation occurring in the endoplasmic reticulum and Golgi apparatus, this process occurs elsewhere throughout the cell in a highly dynamic fashion, similar to the quintessential posttranslational modification, phosphorylation. This more recently described posttranslational modification, the β-O-linkage of N-acetylglucosamine (i.e., O-GlcNAc) to nucleocytoplasmic proteins, represents an under-investigated area of biology. This signaling system operates in all of the tissues examined and seems to have persisted throughout all multi-cellular eukaryotes. Thus, it comes with little surprise that O-GlcNAc signaling is an integral system and viable target for biomedical investigation. This system may be a boundless source for insight into a variety of diseases and yield numerous opportunities for drug design. This Perspective will address recent insights into O-GlcNAc signaling in the cardiovascular system as a paradigm for its involvement in other biological systems.
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影响因子：
3.8
作者：
Farook, VS;Bogardus, C;Prochazka, M
通讯作者：
Prochazka, M
影响因子：
5.5
作者：
Champattanachai, Voraratt;Marchase, Richard B.;Chatham, John C.
通讯作者：
Chatham, John C.
影响因子：
2.9
作者：
Cheng, XG;Cole, RN;Hart, GW
通讯作者：
Hart, GW
DOI：
10.1073/pnas.0601931103
发表时间：
2006-08-08
影响因子：
11.1
作者：
Forsythe, Michele E.;Love, Dona C.;Hanover, John A.
通讯作者：
Hanover, John A.
影响因子：
5.5
作者：
Champattanachai, Voraratt;Marchase, Richard B.;Chatham, John C.
通讯作者：
Chatham, John C.