OXA-163-Producing Klebsiella pneumoniae in Cairo, Egypt, in 2009 and 2010
OXA-163-Producing Klebsiella pneumoniae in Cairo, Egypt, in 2009 and 2010
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DOI：
10.1128/jcm.06710-11
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发表时间：
2012-07-01
影响因子：
9.4
通讯作者：
Mammina, Caterina
中科院分区：
文献类型：
--
作者：
Abdelaziz, Mohammed O.;Bonura, Celestino;Mammina, Caterina
2009年6月和2010年5月在埃及开罗的两例感染病例中鉴定出两种基因上不相关的携带OXA-163的肺炎克雷伯菌菌株。此前仅在阿根廷报告了产OXA-163的肠杆菌科。两名患者均无出国旅行史。这种新发现的能够水解头孢菌素类和碳青霉烯类的OXA-48相关β-内酰胺酶的出现在OXA-48流行的地理区域尤其令人担忧，并且抗生素耐药性的有效监测在很大程度上是负担不起的。
Two genetically unrelated OXA-163-carrying Klebsiella pneumoniae strains were identified from two infection cases in June 2009 and May 2010 in Cairo, Egypt. OXA-163-producing Enterobacteriaceae had been previously reported in Argentina only. Both patients had no history of travel abroad. The emergence of this newly recognized OXA-48-related beta-lactamase able to hydrolyze cephalosporins and carbapenems is especially worrying in a geographic area where OXA-48 is endemic and effective surveillance for antibiotic resistance is largely unaffordable.