Epithelial-mesenchymal transition, TGF-β, and osteopontin in wound healing and tissue remodeling after injury.
Epithelial-mesenchymal transition, TGF-β, and osteopontin in wound healing and tissue remodeling after injury.
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DOI：
10.1097/bcr.0b013e318240541e
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Kuo PC
中科院分区：
文献类型：
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作者：
Weber CE;Li NY;Wai PY;Kuo PC
上皮-间质转化（EMT）是热烧伤或其他损伤后伤口愈合和组织重塑所必需的过程。EMT的特征在于上皮细胞的表型变化，使其非极性，细胞间粘附减少，运动性增加，细胞骨架结构的变化类似于间充质干细胞。关于热烧伤伤口的愈合，伤口愈合的许多方面需要细胞经历这些表型变化;下面的综述中将描述两个。第一个是上皮细胞分化为肌成纤维细胞，其重建细胞外基质并促进伤口收缩。第二种是角质形成细胞的再上皮化。在文献中鉴定的触发EMT的主要细胞因子信号是转化生长因子（TGF）-β。除了在诱导EMT中的重要作用外，TGF-β在伤口愈合过程中还具有许多其他作用。以下综述将提供证据证明EMT是伤口愈合的中心事件。它还将显示调节量的TGF-β对于适当伤口愈合的重要性。最后，将简要讨论骨桥蛋白与伤口愈合的关系及其与EMT和TGF-β的联系。
Epithelial-mesenchymal transition (EMT) is a process essential to wound healing and tissue remodeling after a thermal burn or other injury. EMT is characterized by phenotypic changes in epithelial cells that render them apolar, with decreased cell-cell adhesions, increased motility, and changes in cytoskeletal architecture similar to mesenchymal stem cells. With regard to healing a thermal burn wound, many facets of wound healing necessitate cells to undergo these phenotypic changes; two will be described in the following review. The first is the differentiation of epithelial cells into myofibroblasts that rebuild the extracellular matrix and facilitate wound contraction. The second is reepithelialization by keratinocytes. The primary cytokine signal identified in the literature that triggers EMT is transforming growth factor (TGF)-β. In addition to its vital role in the induction of EMT, TGF-β has many other roles in the wound healing process. The following review will provide evidence that EMT is a central event in wound healing. It will also show the importance of a regulated amount of TGF-β for proper wound healing. Finally, osteopontin will be briefly discussed with its relation to wound healing and its connections to EMT and TGF-β.