Scientific Opinion on the identification of pesticides to be included in cumulative assessment groups on the basis of their toxicological profile
Scientific Opinion on the identification of pesticides to be included in cumulative assessment groups on the basis of their toxicological profile
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DOI：
10.2903/j.efsa.2013.3293
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发表时间：
2013-07-01
期刊：
影响因子：
3.3
通讯作者：
Van Der Linden, Ton
中科院分区：
文献类型：
--
作者：
Aagaard, Alf;Brock, Theo;Van Der Linden, Ton
欧洲食品安全局要求植物保护产品及其残留物专家组根据农药的毒理学特征，制定一项关于确定农药的意见，以纳入累积评估组（CAG）。2008年，农药残留风险评估小组通过了一项关于农药累积风险评估现有方法的适用性的意见，并提出了一种分层方法，该方法于2009年应用于一组选定的三唑类农药。本意见提出了一种根据现象学效应对农药进行分组的方法，并提供了甲状腺和神经系统的CAG。这种方法可以应用，即使在不了解介导影响的潜在生化事件的情况下，并且基于对支持欧洲批准所有农药的评估报告草案（DAR）的标准化和全面审查，以及欧盟委员会的建议。表现出神经毒性特性的农药活性物质被分配给CAG，用于对神经系统的运动、感觉和自主分支以及神经化学终点产生急性影响。对相同部门/终点的慢性效应和神经病理学效应进行了整理。将对甲状腺系统有不良影响的活性物质分配至CAG，以评估其对C细胞/降钙素系统或滤泡细胞/T3/T4系统的影响。PPR小组指出，由此产生的类别包括许多农药，而且个别农药可能出现在几个类别中，因此用于进行累积风险评估的数据输入量相当大。虽然有些有环芳烃含有大量的农药，但从有环芳烃本身的大小几乎不能推断出累积风险的迹象。PPR专家组建议，该方法适用于所有主要器官/系统，但所用方法应被视为针对农药。(C)欧洲食品安全局，2014年。
The European Food Safety Authority asked the Panel on Plant Protection Products and their Residues to develop an Opinion on the identification of pesticides to be included in cumulative assessment groups (CAGs) on the basis of their toxicological profile. In 2008, the PPR Panel adopted an Opinion on the suitability of existing methodologies for cumulative risk assessment of pesticides and a tiered approach was proposed, which was applied to a selected group of triazole pesticides in 2009. The present Opinion suggests a methodology for grouping of pesticides based on phenomenological effects and provides CAGs for the thyroid and nervous system. This approach can be applied even when the underlying biochemical events mediating the effects are not understood, and is based on a standardised and thorough review of Draft Assessment Reports (DARs) supporting the approval of all pesticides in Europe, and on recommendations from the European Commission. Pesticidal active substances exhibiting neurotoxic properties were allocated to CAGs for acute effects on motor, sensory and autonomic divisions of the nervous system and neurochemical endpoints. Chronic effects across the same divisions/endpoints and neuropathological effects were collated. Active substances having adverse effects on the thyroid system were allocated to CAGs for effects either on C-cells/the calcitonin system or on follicular cells/the T3/T4 system. The PPR Panel notes that the resulting groups encompass many pesticides and also that individual pesticides could appear in several groups and therefore the data entries for performing cumulative risk assessment (CRA) are of considerable magnitude. Although some CAGs contain a large number of pesticides, little indication of cumulative risk may be inferred from the size of CAGs per se. The PPR Panel recommends that the methodology is implemented for all major organ/systems but the approach used should be considered specific for pesticides. (C) European Food Safety Authority, 2014.