ENHANCEMENT OF 5-HT-INDUCED ANOREXIA - A TEST OF THE REVERSIBILITY OF MONOAMINE-OXIDASE INHIBITORS
ENHANCEMENT OF 5-HT-INDUCED ANOREXIA - A TEST OF THE REVERSIBILITY OF MONOAMINE-OXIDASE INHIBITORS
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DOI：
10.1007/bf00444703
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发表时间：
1989-01-01
影响因子：
3.4
通讯作者：
YU, PH
中科院分区：
文献类型：
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作者：
FLETCHER, PJ;YU, PH
皮下注射1 mg/kg 5-羟色胺（5-HT）可减少大鼠对10%蔗糖溶液的摄入。单次注射单胺氧化酶抑制剂（MAOI）氯吉林增强5-HT的厌食作用。这种作用在注射后持续2、24、48、72和96 h。氯吉林治疗几乎完全抑制A型单胺氧化酶在肝脏中的活性在2小时后注射。到120 h时，5-HT诱导的厌食增强消失，MAO-A活性恢复到对照值的80%。这些结果表明，氯吉林的作用是持久的和不可逆的。溴法罗明（5 mg/kg）和环莫沙酮（20 mg/kg）也能增强5-HT的减食欲作用。当24 h后给予5-HT时，未观察到溴法罗明和环莫沙酮的增强作用。这些结果表明，溴法罗明和西莫沙酮是体内MAO-A活性的短效可逆抑制剂。吗氯贝胺（30 mg/kg）未能增强注射后2和24 h的5-HT的厌食作用。MAOIs对5-HT诱导的厌食的增强作用可能是研究其可逆性程度和作用时间过程的一个有用的行为学试验。
Subcutaneous injection of 1 mg/kg 5-hydroxytryptamine (5-HT) reduced the intake of a 10% sucrose solution in rats. A single injection of the monoamine oxidase inhibitor (MAOI) clorgyline enhanced the anorectic effect of 5-HT. Such an effect persists 2, 24, 48, 72 and 96 h after injection. The clorgyline treatment almost completely inhibited type A MAO activity in the liver at 2 h post-injection. By 120 h, the time at which potentiation of 5-HT induced anorexia disappeared, MAO-A activity had returned to 80% of control values. These results demonstrate that the clorgyline effect is long-lasting and irreversible. Brofaromine (5 mg/kg) and cimoxatone (20 mg/kg) also enhanced the anorectic effect of 5-HT injected 2 h later. The potentiating effects of brofaromine and cimoxatone were not observed when 5-HT was administered 24 h later. These results indicate that brofaromine and cimoxatone are short-acting, reversible inhibitors of MAO-A activity in vivo. Moclobemide (30 mg/kg) failed to enhance the anorectic action of 5-HT injected 2 and 24 h later. The potentiation of 5-HT induced anorexia may be a useful behavioral test for investigating the degree of reversibility, and time course of action of MAOIs.