The Marshall R. Urist Young Investigator Award
The Marshall R. Urist Young Investigator Award
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马歇尔·乌里斯特青年研究员奖
DOI：
10.1097/00003086-199712000-00034
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发表时间：
1997
影响因子：
4.2
通讯作者：
R. Gelberman
中科院分区：
文献类型：
--
作者：
J. Seiler;C. Chu;D. Amiel;S. Woo;R. Gelberman
To examine the hypothesis that different types of dense regular connective tissue may have different repair mechanisms within the synovial space, intrasynovial and extrasynovial autogenous donor flexor tendon grafts were placed within the synovial sheaths of the medial and lateral forepaw digits of dogs. Histologic, ultrastructural, biochemical, and biomechanical analyses were done between 10 days and 6 weeks after tendon grafting. Intrasynovial tendon grafts remained viable when transferred to the synovial space and appeared to heal through an intrinsic process with preservation of the gliding surface and improved functional characteristics. Extrasynovial tendon grafts functioned as a scaffolding for the early ingrowth of new vessels and cells. Early cellular necrosis consistently was followed by the ingrowth of fibrovascular adhesions from the periphery. The formation of dense peripheral adhesions, obliterating the gliding surface of the tendon, led to diminished tendon excursion and proximal interphalangeal joint rotation.
