Development of an Inline Dry Powder Inhaler for Oral or Trans-Nasal Aerosol Administration to Children
Development of an Inline Dry Powder Inhaler for Oral or Trans-Nasal Aerosol Administration to Children
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DOI：
10.1089/jamp.2019.1540
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发表时间：
2019-08-29
影响因子：
3.4
通讯作者：
Longest, Worth
中科院分区：
文献类型：
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作者：
Farkas, Dale;Hindle, Michael;Longest, Worth
背景：干粉吸入器（DPI）具有许多优点，例如快速输送大剂量吸入药物；然而，由于肺输送效率低且设备操作困难，通常避免在儿童中使用 DPI。本研究的目的是开发一种高效的内联 DPI，用于对儿童进行气雾疗法，并可选择使用口腔或经鼻方法。方法：开发了一种内联 DPI，它由空心入口和出口毛细管、粉末室以及鼻或口腔接口组成。使用通气袋或压缩空气来驱动该装置，同时提供与 5 岁儿童一致的完全深吸气。粉末室部分填充有质量为 10 mg 的模型喷雾干燥赋形剂增强生长粉末制剂。通过级联撞击来表征装置气雾化，并评估通过口腔和鼻体外模型的气雾传播。结果：当所有驱动空气都通过粉末室（无旁路流）时，实现了最佳设备性能，从而产生气溶胶平均质量中值空气动力学直径 (MMAD)
Background: Dry powder inhalers (DPIs) offer a number of advantages, such as rapid delivery of high-dose inhaled medications; however, DPI use in children is often avoided due to low lung delivery efficiency and difficulty in operating the device. The objective of this study was to develop a high-efficiency inline DPI for administering aerosol therapy to children with the option of using either an oral or trans-nasal approach. Methods: An inline DPI was developed that consisted of hollow inlet and outlet capillaries, a powder chamber, and a nasal or oral interface. A ventilation bag or compressed air was used to actuate the device and simultaneously provide a full deep inspiration consistent with a 5-year-old child. The powder chamber was partially filled with a model spray-dried excipient enhanced growth powder formulation with a mass of 10 mg. Device aerosolization was characterized with cascade impaction, and aerosol transmissions through oral and nasal in vitro models were assessed. Results: Best device performance was achieved when all actuation air passed through the powder chamber (no bypass flow) resulting in an aerosol mean mass median aerodynamic diameter (MMAD)