PET imaging of amyloid deposition in patients with mild cognitive impairment
PET imaging of amyloid deposition in patients with mild cognitive impairment
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DOI：
10.1016/j.neurobiolaging.2007.03.029
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发表时间：
2008-10-01
影响因子：
4.2
通讯作者：
Nordberg, Agneta
中科院分区：
文献类型：
--
作者：
Forsberg, Anton;Engler, Henry;Nordberg, Agneta
识别患有AD高风险的受试者具有重要的临床价值。我们之前发现，淀粉样蛋白正电子发射断层扫描 (PET) 示踪剂 PIB 在 AD 患者和健康对照 (HC) 之间的大脑保留方面表现出显着差异。 21 名诊断为 MCI 的患者（平均年龄 63.3 +/- 7.8 (S.D.) 岁）接受了 C-11-PIB 和 F-18-氟脱氧葡萄糖 (FDG) 的 PET 研究，以测量脑葡萄糖代谢、认知功能评估和脑脊液采样。参考组数据分别来自 27 名 AD 患者和 6 名健康对照。均用于比较。与 HC 和 AD 患者相比，MCI 患者的平均皮质 PIB 保留处于中等水平。 7 名在 Lit 临床随访后转为 AD（8.1 +/- 6.0 (S.D.) 个月）的 MCI 患者分别比未转为 MCI 患者和 HC 患者表现出显着更高的 PI B 保留（ps < 0.01）。 MCI 转换器中的 PIB 保留与 AD 患者相当 (p > 0.01)。在 MCI 患者中观察到 PI B 保留与 CSF A beta(1-42) 之间的相关性。分别是总 Tau 和情景记忆。 (C) 2007 年，爱思唯尔公司出版。
It is of great clinical value to identify Subjects at a high risk of developing AD. We previously found that the amyloid positron emission tomography (PET) tracer PIB showed a robust difference in retention in the brain between AD patients and healthy controls (HC). Twenty-one patients diagnosed with MCI (mean age 63.3 +/- 7.8 (S.D.) years) Underwent PET Studies with C-11-PIB, and F-18-fluoro-deoxy-glucose (FDG) to measure cerebral glucose metabolism, its well as assessment of cognitive function and CSF sampling. Reference group data from 27 AD patients and 6 healthy controls, respectively. were Used for comparison. The mean cortical PIB retention for the MCI patients was intermediate compared to HC and AD. Seven MCI patients that later Lit clinical follow-up converted to AD (8.1 +/- 6.0 (S.D.) months) showed significant higher PI B retention compared to non-converting MCI patients and HC, respcctively (ps < 0.01). The PIB retention in MCI converters was comparable to AD patients (p > 0.01). Correlations were observed in the MCI patients between PI B retention and CSF A beta(1-42). total Tau and episodic memory, respectively. (C) 2007 Published by Elsevier Inc.