Short- and Long-Term Effects of Real-Time Continuous Glucose Monitoring in Patients With Type 2 Diabetes
Short- and Long-Term Effects of Real-Time Continuous Glucose Monitoring in Patients With Type 2 Diabetes
复制标题
DOI：
10.2337/dc11-1438
复制
发表时间：
2012-01-01
期刊：
影响因子：
16.2
通讯作者：
Ehrhardt, Nicole M.
中科院分区：
文献类型：
--
作者：
Vigersky, Robert A.;Fonda, Stephanie J.;Ehrhardt, Nicole M.
为了确定是否短时间，实时连续血糖监测（RT-CGM）有长期有益的血糖与2型糖尿病患者谁不对餐时insulin.Research设计和方法，这是一个随机对照试验的100名成人2型糖尿病谁不对餐时胰岛素。本研究比较了12周间歇性RT-CGM与自我血糖监测（SMBG）在40周随访期内对血糖控制的影响。受试者接受糖尿病护理，从他们的常规供应商没有治疗干预的研究team. Prophets-有一个显着的差异，A1 C在3个月的积极干预结束时，在随访期间持续。第12、24、38和52周时，RT-CGM组的平均未校正A1 C分别降低1.0、1.2、0.8和0.8%，SMBG组分别降低0.5、0.5、0.5和0.2%（P = 0.04）。在调整协变量后，RT-CGM组在研究过程中A1 C的下降幅度显著大于SMBG组（P < 0.0001）。按照方案使用RT-CGM（>= 48天）的受试者改善最多（P < 0.0001）。在RT-CGM组的改善发生没有更大的强化药物治疗相比，在SMBGgroup.CONCLUSIONS-subjects 2型糖尿病不对餐时胰岛素谁使用RT-CGM间歇12周显着改善血糖控制在12周，并持续改善没有RT-CGM在40周的随访期间，与那些谁只使用SMBG。
OBJECTIVE-To determine whether short-time, real-time continuous glucose monitoring (RT-CGM) has long-term salutary glycemic effects in patients with type 2 diabetes who are not on prandial insulin.RESEARCH DESIGN AND METHODS-This was a randomized controlled trial of 100 adults with type 2 diabetes who were not on prandial insulin. This study compared the effects of 12 weeks of intermittent RT-CGM with self-monitoring of blood glucose (SMBG) on glycemic control over a 40-week follow-up period. Subjects received diabetes care from their regular provider without therapeutic intervention from the study team.RESULTS-There was a significant difference in A1C at the end of the 3-month active intervention that was sustained during the follow-up period. The mean, unadjusted A1C decreased by 1.0, 1.2, 0.8, and 0.8% in the RT-CGM group vs. 0.5, 0.5, 0.5, and 0.2% in the SMBG group at 12, 24, 38, and 52 weeks, respectively (P = 0.04). There was a significantly greater decline in A1C over the course of the study for the RT-CGM group than for the SMBG group, after adjusting for covariates (P < 0.0001). The subjects who used RT-CGM per protocol (>= 48 days) improved the most (P < 0.0001). The improvement in the RT-CGM group occurred without a greater intensification of medication compared with those in the SMBG group.CONCLUSIONS-Subjects with type 2 diabetes not on prandial insulin who used RT-CGM intermittently for 12 weeks significantly improved glycemic control at 12 weeks and sustained the improvement without RT-CGM during the 40-week follow-up period, compared with those who used only SMBG.