Cancer Cells Exploit Notch Signaling to Redefine a Supportive Cytokine Milieu.
Cancer Cells Exploit Notch Signaling to Redefine a Supportive Cytokine Milieu.
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DOI：
10.3389/fimmu.2018.01823
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发表时间：
2018
影响因子：
7.3
通讯作者：
Platonova N
中科院分区：
文献类型：
--
作者：
Colombo M;Mirandola L;Chiriva-Internati M;Basile A;Locati M;Lesma E;Chiaramonte R;Platonova N
在器官发育过程中，Noch信号在相邻细胞之间的交流中起着举足轻重的作用，它控制着细胞分化的几个过程。Notch介导的通讯可能通过Notch受体与相邻细胞上的配体相互作用，或通过旁分泌/内分泌方式，通过可调节远端细胞之间通讯的可溶性分子发生。Notch通路的失调会导致许多疾病，包括癌症。Notch过度激活可能是由Notch相关基因突变、上游通路失调或微环境信号引起的。癌细胞可能会利用这种异常信号来“教育”周围的微环境细胞，使其倾向于亲肿瘤的行为。这可能是因为肿瘤细胞分泌的关键细胞因子，也可能是通过激活基质细胞中的Notch信号而涉及微环境的，这一事件由细胞与细胞之间的直接接触介导，并导致几种促肿瘤细胞因子的分泌增加。到目前为止，综述文章主要集中在Notch在特定肿瘤背景或免疫细胞群中的作用。在这里，我们对Notch介导的病理相互作用在不同肿瘤环境中的结果以及参与这一过程的分子和细胞介质进行了全面的综述。我们描述了癌症中Notch失调如何改变细胞因子网络及其在肿瘤进展和抗肿瘤免疫反应中的结果。
Notch signaling is a well-known key player in the communication between adjacent cells during organ development, when it controls several processes involved in cell differentiation. Notch-mediated communication may occur through the interaction of Notch receptors with ligands on adjacent cells or by a paracrine/endocrine fashion, through soluble molecules that can mediate the communication between cells at distant sites. Dysregulation of Notch pathway causes a number of disorders, including cancer. Notch hyperactivation may be caused by mutations of Notch-related genes, dysregulated upstream pathways, or microenvironment signals. Cancer cells may exploit this aberrant signaling to “educate” the surrounding microenvironment cells toward a pro-tumoral behavior. This may occur because of key cytokines secreted by tumor cells or it may involve the microenvironment through the activation of Notch signaling in stromal cells, an event mediated by a direct cell-to-cell contact and resulting in the increased secretion of several pro-tumorigenic cytokines. Up to now, review articles were mainly focused on Notch contribution in a specific tumor context or immune cell populations. Here, we provide a comprehensive overview on the outcomes of Notch-mediated pathological interactions in different tumor settings and on the molecular and cellular mediators involved in this process. We describe how Notch dysregulation in cancer may alter the cytokine network and its outcomes on tumor progression and antitumor immune response.
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影响因子：
6.7
作者：
Auderset F;Schuster S;Coutaz M;Koch U;Desgranges F;Merck E;MacDonald HR;Radtke F;Tacchini-Cottier F
通讯作者：
Tacchini-Cottier F
DOI：
10.1007/978-3-0348-0837-8_16
发表时间：
2014-01-01
期刊：
INFLAMMATION AND CANCER
影响因子：
--
作者：
Bishayee, Anupam
通讯作者：
Bishayee, Anupam
影响因子：
11.5
作者：
Ahern, Elizabeth;Harjunpaa, Heidi;Smyth, Mark J.
通讯作者：
Smyth, Mark J.
影响因子：
4.4
作者：
Asano, Naoki;Watanabe, Tomohiro;Strober, Warren
通讯作者：
Strober, Warren
影响因子：
30.5
作者：
Andoniou, CE;van Dommelen, SLH;Degli-Esposti, MA
通讯作者：
Degli-Esposti, MA