The Dorsal Aorta Initiates a Molecular Cascade That Instructs Sympatho-Adrenal Specification
The Dorsal Aorta Initiates a Molecular Cascade That Instructs Sympatho-Adrenal Specification
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DOI：
10.1126/science.1222369
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发表时间：
2012-06-22
期刊：
影响因子：
56.9
通讯作者：
Takahashi, Yoshiko
中科院分区：
文献类型：
--
作者：
Saito, Daisuke;Takase, Yuta;Takahashi, Yoshiko
自主神经系统起源于神经嵴，包括交感神经元和肾上腺髓质。结合禽类血管特异性基因操作和小鼠遗传学，我们解决了一个长期存在的问题，即神经嵴细胞（NCC）如何在胚胎发育过程中产生交感神经和髓质谱系。我们发现，背主动脉作为一个形态发生的信号中心，协调NCC迁移和细胞谱系分离。由背主动脉产生的骨形态发生蛋白（BMP）对于主动脉旁区域中趋化因子基质细胞衍生因子-1（SDF 1）和神经调节蛋白1的产生至关重要，其充当早期迁移的化学引诱物。随后，BMP信号传导直接参与交感神经-髓质分离。这项研究提供了对复杂的发育信号级联的见解，指导神经血管相互作用指导胚胎发育的最早事件之一。
The autonomic nervous system, which includes the sympathetic neurons and adrenal medulla, originates from the neural crest. Combining avian blood vessel-specific gene manipulation and mouse genetics, we addressed a long-standing question of how neural crest cells (NCCs) generate sympathetic and medullary lineages during embryogenesis. We found that the dorsal aorta acts as a morphogenetic signaling center that coordinates NCC migration and cell lineage segregation. Bone morphogenetic proteins (BMPs) produced by the dorsal aorta are critical for the production of the chemokine stromal cell-derived factor-1 (SDF 1) and Neuregulin 1 in the para-aortic region, which act as chemoattractants for early migration. Later, BMP signaling is directly involved in the sympatho-medullary segregation. This study provides insights into the complex developmental signaling cascade that instructs one of the earliest events of neurovascular interactions guiding embryonic development.