Alcoholic Liver Disease in Asia, Europe, and North America.
Alcoholic Liver Disease in Asia, Europe, and North America.
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DOI：
10.1053/j.gastro.2016.02.043
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发表时间：
2016-06
期刊：
影响因子：
29.4
通讯作者：
McCaughan GW
中科院分区：
文献类型：
--
作者：
Liangpunsakul S;Haber P;McCaughan GW
酒精性肝病（ALD）包括一系列临床疾病和肝组织变化，可以通过病理学分析检测到。这些范围从脂肪变性到与炎症相关的肝脏疾病的更严重的体征和症状，例如在酒精性肝炎或肝硬化患者中观察到的那些。虽然酒精消费和肝脏疾病之间的关系已经建立，但只有少数过量饮酒的人会出现严重的酒精相关疾病。个体间对酒精毒性作用的敏感性差异已得到广泛研究，包括饮酒模式、性别、环境因素（如饮食）和遗传因素，这些因素在世界不同地区差异很大。ALD在亚洲许多地区越来越普遍，但在西欧正在减少。治疗方法，包括药物供应、护理模式和移植方法，在各区域之间存在差异。
Alcoholic liver diseases (ALD) comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from steatosis to more severe signs and symptoms of liver disease associated with inflammation, such as those observed in patients with alcoholic hepatitis or cirrhosis. Although the relationship between alcohol consumption and liver disease is well established, severe alcohol-related morbidities develop in only a minority of people who consume alcohol in excess. Inter-individual differences in susceptibility to the toxic effects of alcohol have been extensively studied—they include pattern of alcohol consumption, sex, environmental factors (such as diet), and genetic factors, which vary widely among different parts of the world. ALD is becoming more common in many parts of Asia but is decreasing in Western Europe. Treatment approaches, including availability of medications, models of care, and approach to transplantation, differ among regions.