Benign alveolar ridge keratosis (oral lichen simplex chronicus): A distinct clinicopathologic entity
Benign alveolar ridge keratosis (oral lichen simplex chronicus): A distinct clinicopathologic entity
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DOI：
10.1016/j.jaad.2007.07.011
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发表时间：
2008-01-01
影响因子：
13.8
通讯作者：
Woo, Sook-Bin
中科院分区：
文献类型：
--
作者：
Natarajan, Easwar;Woo, Sook-Bin
良性牙槽嵴角化病是一种常见的良性白色丘疹或斑块，发生在上颌或下颌牙槽嵴角化的牙龈上，可能起源于创伤/摩擦，具有典型的组织学特征，与皮肤慢性单纯性地衣相似。这是一项回顾性研究，108个连续标本显示良性肺泡脊角化病在36个月期间加入的典型组织病理学特征。男女比例为3.7:1。发生在附着龈，磨牙后区和无牙槽嵴分别占51%和49%。19%为双侧，所有双侧病例均在后磨牙垫上。通过邮寄问卷的方式获取27例患者的详细临床资料。组织学上，病变的特点是中度至显著的过度角化症和楔形多粒病。上皮表现出轻微的表面乳头状瘤和棘层增生，呈长而锥形的网状脊状，经常在基部吻合。炎症一般不明显。这些特征是相似的，如果不完全相同的慢性单纯性地衣的皮肤，一种良性状况引起的慢性刺激。随机选择10例患者进行p16INK4A（p16）免疫染色，p16是一种表达于发育不良上皮中的肿瘤抑制蛋白。所有病变p16均为阴性。良性肺泡嵴角化病是一种特殊的临床病理实体，应从白斑的类别中删除，因为目前临床白色病变具有特定的，一致可识别的组织学外观。
Benign alveolar ridge keratosis is a common benign white papule or plaque that occurs on the keratinized gingiva of the maxillary or mandibular alveolar ridge that is probably traumatic/frictional in origin, with characteristic histologic features, similar to those of lichen simplex chronicus of the skin. This is a retrospective study of 108 consecutive specimens displaying characteristic histopathologic features of benign alveolar ridge keratosis accessioned during a 36-month period. There was a male:female ratio of 3.7:1. It occurred on the attached gingiva, with the retromolar area and the edentulous alveolar ridge involved in 51% and 49% of cases, respectively., 19% were bilateral and all bilateral cases were on the retromolar pad. Detailed clinical information was available on 27 cases by a mail-in questionnaire. Histologically, the lesions were characterized by moderate to marked hyperorthokeratosis and wedge-shaped hypergranulosis. The epithelium exhibited slight surface papillomatosis and acanthosis in the form of long, tapered rete ridges that frequently anastomosed at the base. There was generally insignificant inflammation. These features are similar if not identical to lichen simplex chronicus of the skin, a benign condition caused by chronic irritation. Ten randomly selected cases were immunostained for p16INK4A(p16), a tumor suppressor protein expressed in dysplastic epithelium. All lesions were negative for p16. Benign alveolar ridge keratosis is a specific clinicopathologic entity that should be removed from the category of leukoplakia as is currently the practice for clinical white lesions with a specific, consistently recognizable histologic appearance.