Trait versus state aspects of the MMPI during the early course of schizophrenia.
Trait versus state aspects of the MMPI during the early course of schizophrenia.
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DOI：
10.1016/s0022-3956(98)00062-4
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发表时间：
1999-05
影响因子：
4.8
通讯作者：
K. Subotnik;K. Nuechterlein;M. Green
中科院分区：
文献类型：
--
作者：
K. Subotnik;K. Nuechterlein;M. Green
明尼苏达多相人格调查表（MMPI）-168项目版本的分数进行了检查，在临床缓解期和精神病的新发精神分裂症患者（n=19），并在可比的时间间隔人口统计学匹配的正常参与者（n=19）。为了确定诊断特异性，还检查了双相情感障碍缓解期参与者（n=12）的MMPI。区分稳定脆弱性指标、介导脆弱性因素和精神病理学发作指标的方法改编自Nuechterlein和Dawson，1984年。MMPI量表Pa、Sc和效度量表F表现出特质性和状态性相结合的特点，具有中介脆弱性因素的特点。这些量表反映了精神病发作期间发生的变化，但也明显挖掘了持续到临床缓解期的个性特征。出乎意料的是，一些MMPI量表通常与精神病性障碍（即Hs，D和Hy）不相关的精神分裂症患者在精神病性和临床缓解状态中显着高于正常参与者。在临床缓解期，量表Hs、D和Hy的较高评分显示出精神分裂症相对于双相情感障碍的一些特异性。虽然MMPI-168量表Pd和Pt符合脆弱性指标的模式，但不确定它们是否属于稳定亚型或中介亚型。MMPI评分继续高于缓解期的正常样本可能反映了持久的脆弱性因素或精神分裂症的影响，以及个人试图科普这种疾病。需要对一级亲属进行研究，以提供聚合证据，证明某些人格特征反映了精神分裂症的遗传易感性。
Scores on the Minnesota Multiphasic Personality Inventory (MMPI)-168 item version were examined during periods of clinical remission and of psychosis for recent-onset schizophrenia patients (n=19) and at comparable time intervals for demographically matched normal participants (n=19). To determine diagnostic specificity, MMPIs for participants with bipolar affective disorder in remission (n=12) were also examined. Methods for distinguishing between stable vulnerability indicators, mediating vulnerability factors and episode indicators of psychopathology were adapted from Nuechterlein and Dawson, 1984. MMPI scales Pa, Sc and validity scale F showed a combination of trait and state qualities, characteristic of mediating vulnerability factors. These scales reflect changes that occur during psychotic episodes but also apparently tap personality characteristics that endure into periods of clinical remission. Unexpectedly, some MMPI scales that are not typically associated with psychotic disorders (i.e. Hs, D, and Hy) were significantly higher in schizophrenia patients across psychotic and clinically remitted states than in normal participants. In clinical remission, higher scores on scales Hs, D and Hy, showed some specificity to schizophrenia relative to bipolar disorder. While MMPI-168 scales Pd and Pt fit the pattern for vulnerability indicators, it was uncertain whether they belonged to the stable versus mediating subtype. MMPI scores that continue to be higher in remission than in a normal sample may reflect either enduring vulnerability factors or the impact of schizophrenia and the individuals attempts to cope with the disorder. Studies of first-degree relatives will be needed to provide converging evidence that certain personality characteristics reflect genetic predisposition to schizophrenia.