Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis
Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis
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DOI：
10.1254/jphs.11188sc
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发表时间：
2012-08-01
影响因子：
3.5
通讯作者：
Miyaura, Chisato
中科院分区：
文献类型：
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作者：
Tominari, Tsukasa;Hirata, Michiko;Miyaura, Chisato
诺比莱汀是一种多甲氧基黄酮类化合物(PMF)，可抑制雌激素缺乏的卵巢切除小鼠的全身骨吸收并维持骨量。这项研究考察了PMF，nobiletin和Tangeretin对内毒素诱导的骨吸收的抗炎作用。在RAW264.7巨噬细胞中，诺比莱汀和橘皮素能抑制脂多糖诱导的破骨细胞形成和骨吸收，并抑制核因子kappaB受体激活剂诱导的破骨细胞生成。诺比莱汀通过抑制脂多糖诱导的骨吸收，明显恢复了牙周炎小鼠模型的牙槽骨量。因此，PMF可能为牙周骨丢失提供一种新的治疗方法。
Nobiletin, a polymethoxy flavonoid (PMF), inhibits systemic bone resorption and maintains bone mass in estrogen-deficient ovariectomized mice. This study examined the anti-inflammatory effects of PMFs, nobiletin, and tangeretin on lipopolysaccharide (LPS)-induced bone resorption. Nobiletin and tangeretin suppressed LPS-induced osteoclast formation and bone resorption and suppressed the receptor activator of NF kappa B ligand-induced osteoclastogenesis in RAW264.7 macrophages. Nobiletin clearly restored the alveolar bone mass in a mouse experimental model for periodontitis by inhibiting LPS-induced bone resorption. PMFs may therefore provide a new therapeutic approach for periodontal bone loss.