Geometric experience sculpts the development and dynamics of hippocampal sequential cell assemblies.
Geometric experience sculpts the development and dynamics of hippocampal sequential cell assemblies.
复制标题
几何经验塑造了海马序列细胞组件的发育和动力学。
DOI：
10.1101/2023.12.04.570026
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Dragoi,George
中科院分区：
文献类型：
--
作者：
Farooq,Usman;Dragoi,George
欧几里得空间是我们生活的世界的结构。几何经验是否以及如何塑造我们对世界的时空表征仍然是未知的。我们剥夺了大鼠的经验与欧几里德几何的关键特征饲养在半透明的球体，并比较活动的大海马神经元合奏在导航和睡眠与长方体笼饲养的控制。从出生开始的球体养育允许出现准确的神经元系综空间代码和预配置和塑料时间压缩的神经元序列。然而，球饲养导致减少个人的地方细胞调谐，类似的神经元映射不同的轨道端/角，和受损的神经元模式分离和可塑性的多个线性轨道的经验，部分驱动减少预配置的网络剧目。随后的经验与多个线性环境在四天内在很大程度上扭转了这些影响，证实了海马神经发育的几何经验的作用。因此，早期生活中的经验与欧几里德几何丰富的海马剧目的预配置的神经元模式选择对独特的代表性和歧视的多个线性环境。
Euclidean space is the fabric of the world we live in. Whether and how geometric experience shapes our spatial-temporal representations of the world remained unknown. We deprived rats of experience with crucial features of Euclidean geometry by rearing them inside translucent spheres, and compared activity of large hippocampal neuronal ensembles during navigation and sleep with that of cuboid cage-reared controls. Sphere-rearing from birth permitted emergence of accurate neuronal ensemble spatial codes and preconfigured and plastic time-compressed neuronal sequences. However, sphere-rearing led to diminished individual place cell tuning, similar neuronal mapping of different track ends/corners, and impaired neuronal pattern separation and plasticity of multiple linear track experiences, partly driven by reduced preconfigured network repertoires. Subsequent experience with multiple linear environments over four days largely reversed these effects, substantiating the role of geometric experience on hippocampal neural development. Thus, early-life experience with Euclidean geometry enriches the hippocampal repertoire of preconfigured neuronal patterns selected toward unique representation and discrimination of multiple linear environments.