Agreement and repeatability of central corneal thickness measurements by four different optical devices and an ultrasound pachymeter
Agreement and repeatability of central corneal thickness measurements by four different optical devices and an ultrasound pachymeter
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DOI：
10.1007/s10792-018-0983-2
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发表时间：
2019-07-01
影响因子：
1.6
通讯作者：
Onaran, Zafer
中科院分区：
文献类型：
--
作者：
Gokcinar, Nesrin Buyuktortop;Yumusak, Erhan;Onaran, Zafer
目的比较光谱域光学相干断层扫描（OCT）、联合Scheimpflug-Placido系统的角膜地形图（CT）、光学生物测量（OB）、角膜内皮显微镜（SM）和超声测厚术（UP）测量中央角膜厚度（CCT）的可重复性和一致性。Nidek RS-3000 Advance OCT、CSO Sirius联合Scheimpflug-Placido椎间盘系统CT、Nidek AL-Scan基于部分相干干涉法的OB、Tomey EM-3000 SM和Reichert iPac超声测厚仪。还记录了由SM器械软件校正的角膜厚度测量值。结果OCT、CT、OB、SM、校正SM和UP测量的平均CCT分别为544.60 +/- 29.56、536.19 +/- 32.14、528.29 +/-29.45、528.29 +/-29.46、528.29 524.88 ± 32.38、537.88 ± 32.38和545.29 ± 30.75 μ m。两种器械的平均CCT显著不同（p 0.99）。结论不同CCT测量技术的测量结果差异较大，CCT评价和随访应使用同一种或兼容性较好的设备。
Purpose To compare the repeatability and agreement of central corneal thickness (CCT) measurements by spectral-domain optical coherence tomography (OCT), corneal topography (CT) with a combined Scheimpflug-Placido system, optical biometry (OB), specular microscopy (SM), and ultrasound pachymetry (UP).Methods A single observer measured CCT twice in 150 eyes of 150 subjects with each of five devices: Nidek RS-3000 Advance OCT, CSO Sirius combined Scheimpflug-Placido disc system CT, Nidek AL-Scan partial coherence interferometry-based OB, Tomey EM-3000 SM, and Reichert iPac ultrasonic pachymeter. Pachymetry values corrected by the SM device software were also recorded. Levels of agreement between devices were evaluated by Bland-Altman plots with 95% limits of agreement, and repeatability for each device was analysed with intraclass correlation coefficients.Results The mean CCTs measured by OCT, CT, OB, SM, corrected SM, and UP were 544.60 +/- 29.56, 536.19 +/- 32.14, 528.29 +/- 29.45, 524.88 +/- 32.38, 537.88 +/- 32.38, and 545.29 +/- 30.75 mu m, respectively. Mean CCT differed significantly between the devices (p0.99). The range of limits of agreement was the least between OCT and UP.Conclusions Different CCT measurement techniques produce quite different results, so CCT evaluation and follow-up should be performed using the same device or devices with close compatibility.