A systematic study of the pharmacological activities of dopamine antagonists.
A systematic study of the pharmacological activities of dopamine antagonists.
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多巴胺拮抗剂药理活性的系统研究。
DOI：
10.1016/0024-3205(79)90096-1
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发表时间：
1979
期刊：
影响因子：
6.1
通讯作者：
P. Janssen
中科院分区：
文献类型：
--
作者：
C. Niemegeers;P. Janssen
所谓的多巴胺（DA）拮抗剂具有多种药理活性。本文分析了在杨森研究实验室获得的一些比较数据，在一组具有代表性的药理学试验中使用了大量的da拮抗剂。本研究阐明了这些化合物不同药理性质的相对重要性，为该领域进一步有意义的药理学和生化研究提供了工具，并讨论了这些药物的治疗潜力。
The so-called dopamine (DA)-antagonists possess a wide variety of pharmacological activities. The present paper analyses some comparative data that were obtained in the Janssen Research Laboratories, using a large series of DA-antagonists in a representative set of pharmacological tests. This study illustrates the relative importance of the different pharmacological properties of these compounds, provides a tool for further meaningful pharmacological and biochemical research in this area, and discusses the therapeutic potential of these drugs.