Acute health effects of desktop 3D printing (fused deposition modeling) using acrylonitrile butadiene styrene and polylactic acid materials: An experimental exposure study in human volunteers
Acute health effects of desktop 3D printing (fused deposition modeling) using acrylonitrile butadiene styrene and polylactic acid materials: An experimental exposure study in human volunteers
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DOI：
10.1111/ina.12458
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发表时间：
2018-07-01
期刊：
影响因子：
5.8
通讯作者：
Schierl, R.
中科院分区：
文献类型：
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作者：
Guemperlein, I.;Fischer, E.;Schierl, R.
3D打印机越来越多地在家中运行。据报道，这些打印机排放的纳米颗粒提出了一个问题，即3D打印机是否会引发超细颗粒(UFP)对健康的不利影响。我们在单盲、随机、交叉设计中，让26名健康成年人暴露在台式3D打印机的排放物中，使用融合沉积建模(FDM)1小时(高UFP排放的丁腈-苯乙烯[ABS]与低排放的聚乳酸[PLA])。观察暴露前后鼻腔分泌物中细胞因子(IL-1β、IL-6、肿瘤坏死因子-α、干扰素-γ)和ECP、呼出的一氧化氮(FeNO)、尿8-异前列腺素F-2α(8-iso PGF(2α))和自评症状。暴露对8-iso PGF(2α)和鼻腔生物标志物的影响没有显著差异。但两组间差异有统计学意义(P
3D printers are increasingly run at home. Nanoparticle emissions from those printers have been reported, which raises the question whether adverse health effects from ultrafine particles (UFP) can be elicited by 3D printers. We exposed 26 healthy adults in a single-blinded, randomized, cross-over design to emissions of a desktop 3D printer using fused deposition modeling (FDM) for 1hour (high UFP-emitting acrylonitrile butadiene styrene [ABS] vs low-emitting polylactic acid [PLA]). Before and after exposures, cytokines (IL-1 beta, IL-6, TNF-alpha, INF-gamma) and ECP in nasal secretions, exhaled nitric oxide (FeNO), urinary 8-isoprostaglandin F-2 alpha (8-iso PGF(2 alpha)), and self-reported symptoms were assessed. The exposures had no significant differential effect on 8-iso PGF(2 alpha) and nasal biomarkers. However, there was a difference (P