Polymersome-based drug-delivery strategies for cancer therapeutics.
Polymersome-based drug-delivery strategies for cancer therapeutics.
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DOI：
10.4155/tde.14.125
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发表时间：
2015
影响因子：
4.2
通讯作者：
Mallik S
中科院分区：
文献类型：
--
作者：
Anajafi T;Mallik S
聚合物囊泡是由两亲聚合物制备的稳定囊泡，与脂质体相比更稳定。尽管这些纳米囊泡具有许多体外/体内应用的有吸引力的性质，但基于脂质体的药物递送系统在市场上仍然很流行。为了加快转化潜力并提供有医学价值的制剂，聚合物囊泡需要是生物相容性和生物可降解的。本文综述了生物相容性和生物可降解性聚合物囊泡的最新进展，包括智能、靶向和刺激响应性囊泡的设计。
Polymersomes are stable vesicles prepared from amphiphilic polymers and are more stable compared with liposomes. Although these nanovesicles have many attractive properties for in vitro/in vivo applications, liposome-based drug delivery systems are still prevalent in the market. In order to expedite the translational potential and to provide medically valuable formulations, the polymersomes need to be biocompatible and biodegradable. In this review, recent developments for biocompatible and biodegradable polymersomes, including the design of intelligent, targeted, and stimuli-responsive vesicles are summarized.