FLT3 mutation and response to intensive chemotherapy in young adult and elderly patients with normal karyotype
FLT3 mutation and response to intensive chemotherapy in young adult and elderly patients with normal karyotype
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DOI：
10.1016/j.leukres.2003.09.016
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发表时间：
2004-06-01
影响因子：
2.7
通讯作者：
Estey, E
中科院分区：
文献类型：
--
作者：
Beran, M;Luthra, R;Estey, E
分析Flt3基因突变对接受强化化疗的二倍体AML患者预后的影响。176例患者中，单一ITD的频率为30%(60岁：23%)，单一D835突变的频率为2.3%，两者均为2.3%。ITD与CR率无相关性。ITD阳性患者
The prognostic impact of FLT3 mutations on the outcome of patients with diploid AML, treated with intensive chemotherapy, was analyzed. In 176 patients, the frequency of single ITD was 30% (60 years: 23%), single D835 mutation 2.3%, and both 2.3%. There was no association between ITD and CR rate. ITD-positive patients