Associations of Recreational Physical Activity and Leisure Time Spent Sitting With Colorectal Cancer Survival
Associations of Recreational Physical Activity and Leisure Time Spent Sitting With Colorectal Cancer Survival
复制标题
DOI：
10.1200/jco.2012.45.9735
复制
发表时间：
2013-03-01
影响因子：
45.3
通讯作者：
Gapstur, Susan M.
中科院分区：
文献类型：
--
作者：
Campbell, Peter T.;Patel, Alpa V.;Gapstur, Susan M.
研究目的：关于休闲体育活动或休闲时间与结直肠癌诊断后生存率之间的关系，目前还知之甚少。本研究探讨了协会的诊断前和诊断后的休闲体育活动和休闲时间花费坐在死亡率之间的patients with colorectal cancer.Patients and MethodsFrom a cohort of adults without colorectal cancer at baseline in 1992-1993，我们确定了2,293名参与者被诊断为浸润性，非转移性结肠直肠癌到2007年年中。在基线，在他们的癌症诊断，并再次在他们的癌症诊断后，参与者完成了详细的问卷调查，其中包括有关信息的娱乐性体育活动和休闲时间花费siting.ResultsDuring最大随访16.1年后，结直肠癌的诊断，846例结直肠癌患者死亡，其中379例结直肠癌。每周从事8.75小时或更多代谢当量（MET）的娱乐性体力活动（相当于每周步行约150分钟）与每周少于3.5 MET小时相比，（诊断前体力活动：相对风险[RR]，0.72; 95% CI，0.58 - 0.89;诊断后体力活动：RR，0.58; 95% CI，0.47 - 0.71）。每天花6个小时或更多的休闲时间坐着，而每天少于3个小时，与更高的全因死亡率相关（诊断前坐位时间：RR，1.36; 95% CI，1.10 ~ 1.68;诊断后坐位时间：RR，1.27;结论结直肠癌诊断前后更多的娱乐性体力活动与较低的死亡率相关，而坐着的时间越长，死亡风险越高。J Clin Oncol 31：876-885. (C)2013年美国临床肿瘤学会
PurposeLittle is known about the association of recreational physical activity or leisure time spent sitting with survival after colorectal cancer diagnosis. This study examined the associations of prediagnosis and postdiagnosis recreational physical activity and leisure time spent sitting with mortality among patients with colorectal cancer.Patients and MethodsFrom a cohort of adults without colorectal cancer at baseline in 1992-1993, we identified 2,293 participants who were diagnosed with invasive, nonmetastatic colorectal cancer up to mid-2007. At baseline, before their cancer diagnosis, and again after their cancer diagnosis, participants completed detailed questionnaires that included information concerning recreational physical activity and leisure time spent sitting.ResultsDuring a maximum follow-up of 16.1 years after colorectal cancer diagnosis, 846 patients with colorectal cancer died, 379 of them from colorectal cancer. Engaging in 8.75 or more metabolic equivalent (MET) hours per week of recreational physical activity (equivalent to approximately 150 minutes per week of walking) compared with fewer than 3.5 MET hours per week was associated with lower all-cause mortality (prediagnosis physical activity: relative risk [RR], 0.72; 95% CI, 0.58 to 0.89; postdiagnosis physical activity: RR, 0.58; 95% CI, 0.47 to 0.71). Spending 6 or more hours per day of leisure time sitting compared with fewer than 3 hours per day was associated with higher all-cause mortality (prediagnosis sitting time: RR, 1.36; 95% CI, 1.10 to 1.68; postdiagnosis sitting time: RR, 1.27; 95% CI, 0.99 to 1.64).ConclusionMore recreational physical activity before and after colorectal cancer diagnosis was associated with lower mortality, whereas longer leisure time spent sitting was associated with higher risk of death. J Clin Oncol 31:876-885. (C) 2013 by American Society of Clinical Oncology