Dracomolphesin A-E, five 3,4-seco-phenylpropanoids with Nrf2 inducing activity from Dracocephalum moldavica
Dracomolphesin A-E, five 3,4-seco-phenylpropanoids with Nrf2 inducing activity from Dracocephalum moldavica
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DOI：
10.1016/j.cclet.2019.09.036
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发表时间：
2020-05-01
影响因子：
9.1
通讯作者：
Ren, Dongmei
中科院分区：
文献类型：
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作者：
Zhang, Huaran;Xu, Lintao;Ren, Dongmei
从龙头草（dragonocephalum moldavica）的地上部分离得到5个具有芳香环开骨架的3,4-仲苯丙素A-E（1-5）。用光谱法结合Mosher法确定了具有绝对构型的结构。值得注意的是，这些化合物是苯丙类化合物芳环裂解产物的一个例子。提出了这些化合物可能的生物合成途径。化合物1、2、4和5被证明是Nrf2通路的激活剂。(C) 2019中国化学学会，中国医学科学院药物研究所。Elsevier B.V.版权所有。
Dracomolphesin A-E (1-5), five 3,4-seco-phenylpropanoids featuring an aromatic ring opened framework, were isolated from the aerial parts of Dracocephalum moldavica. The structures with absolute configurations were determined by spectroscopic methods coupled with Mosher method. Notably, these compounds represented an example of aromatic ring cleavage products of phenylpropanoids. The possible biosynthetic pathway of these compounds was proposed. Compounds 1, 2, 4 and 5 were demonstrated to be Nrf2 pathway activators. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.