Deoxyribonucleic acid cleavage specificity of a series of acridine- and acodazole-iron porphyrins as functional bleomycin models.

Deoxyribonucleic acid cleavage specificity of a series of acridine- and acodazole-iron porphyrins as functional bleomycin models.
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作为功​​能性博莱霉素模型的一系列吖啶-和阿科达唑-铁卟啉的脱氧核糖核酸裂解特异性。

DOI:
10.1021/bi00366a020
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发表时间:
1986
期刊:
影响因子:
2.9
通讯作者:
Dabrowiak,JC
Dabrowiak,JC
中科院分区:
生物学3区
文献类型:
--
作者:
Lown,JW;Sondhi,SM;Ong,CW;Skorobogaty,A;Kishikawa,H;Dabrowiak,JC

文献摘要

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材料和方法材料化学品。次血红素单甲酯(Caughey等人,1966年;缩写:NMR,核磁共振; MS,质谱法; FAB,快速原子轰击; TLC,薄层色谱法; IR,红外光谱法; EDTA,乙二胺四乙酸; Tris-HCl,三羟甲基氨基甲烷;(羟甲基)氨基甲烷盐酸盐; DTT,二硫苏糖醇; 2-ME,2-巯基乙醇; DMF,二甲基甲酰胺; CCC,共价闭合环状; OC,开环; Me 2SO,二甲基亚砜; FT,傅里叶变换; EM,电子显微镜。
Materials and MethodsMaterials Chemicals. Deuterohemin monomethyl ester (Caughey et al., 1966; Lown & Joshua, 1982) was prepared by refluxing1 Abbreviations: NMR, nuclear magnetic resonance; MS, mass spectrometry; FAB, fast atomic bombardment; TLC, thin-layerchromatography; IR, infrared spectroscopy; EDTA, ethylenediaminetetra-acetic acid; Tris-HCl, tris (hydroxymethyl) aminomethane hydrochloride; DTT, dithiothreitol; 2-ME, 2-mercaptoethanol; DMF, dimethylformamide; CCC, covalently closed circular; OC, open circular; Me2SO, dimethyl sulfoxide; FT, Fourier transform; EM, electron microscopy.