The basal ganglia communicate with the cerebellum
The basal ganglia communicate with the cerebellum
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DOI：
10.1073/pnas.1000496107
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发表时间：
2010-05-04
影响因子：
11.1
通讯作者：
Strick, Peter L.
中科院分区：
文献类型：
--
作者：
Bostan, Andreea C.;Dum, Richard P.;Strick, Peter L.
基底神经节和小脑是主要的皮质下结构，不仅影响运动，而且影响认知和情感。这两个结构都接收来自大脑皮层的输入，并向大脑皮层发送输出。因此，基底神经节和小脑与大脑皮层形成多突触回路。基底神经节和小脑环被认为在解剖学上是分开的，并执行不同的功能操作。我们研究了基底神经节输出是否有任何直接的途径影响小脑功能，这是独立的大脑皮层。我们注射狂犬病病毒（RV）到选定的区域的小脑皮质在猕猴和使用逆行transneuronal运输的病毒，以确定多突触输入的注射部位的起源。我们发现，丘脑底核的基底节有一个实质性的双突触投射到小脑皮质。该通路为来自基底神经节的正常和异常信号提供了影响小脑功能的手段。我们以前表明，小脑齿状核有一个双突触投射到基底神经节处理的输入阶段，纹状体。总之，这些结果为基底神经节和小脑之间的双向交流提供了解剖学基础。因此，两个皮层下结构可以连接在一起以形成集成的功能网络。
The basal ganglia and cerebellum are major subcortical structures that influence not only movement, but putatively also cognition and affect. Both structures receive input from and send output to the cerebral cortex. Thus, the basal ganglia and cerebellum form multisynaptic loops with the cerebral cortex. Basal ganglia and cerebellar loops have been assumed to be anatomically separate and to perform distinct functional operations. We investigated whether there is any direct route for basal ganglia output to influence cerebellar function that is independent of the cerebral cortex. We injected rabies virus (RV) into selected regions of the cerebellar cortex in cebus monkeys and used retrograde transneuronal transport of the virus to determine the origin of multisynaptic inputs to the injection sites. We found that the subthalamic nucleus of the basal ganglia has a substantial disynaptic projection to the cerebellar cortex. This pathway provides a means for both normal and abnormal signals from the basal ganglia to influence cerebellar function. We previously showed that the dentate nucleus of the cerebellum has a disynaptic projection to an input stage of basal ganglia processing, the striatum. Taken together these results provide the anatomical substrate for substantial two-way communication between the basal ganglia and cerebellum. Thus, the two subcortical structures may be linked together to form an integrated functional network.