Effect of home blood pressure and gender on estimates of the familial aggregation of blood pressure. The Tecumseh Blood Pressure Study.
Effect of home blood pressure and gender on estimates of the familial aggregation of blood pressure. The Tecumseh Blood Pressure Study.
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家庭血压和性别对血压家族聚集估计的影响。
DOI：
10.1161/01.hyp.20.3.314
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Julius,S
中科院分区：
文献类型：
--
作者：
Jamerson,KA;Schork,N;Julius,S
来自单次诊所访问的血压（BP）读数通常用于调查BP遗传基础的人群研究。我们在特库姆塞血压研究中检查了一级亲属，以比较在诊所-办公室环境中获得的血压读数（两个坐位读数的平均值）与在1周内获得的自我报告的家庭血压读数（14个读数的平均值）的遗传性估计。测试的假设是在1周时间内在家中获得的重复BP读数将具有较少的伪影（即，环境引起的BP变异性），因此将更好地估计真正的“基础”BP，这反过来又将改善遗传力估计。我们和其他人认为真正的基础血压水平是可遗传的。因此，我们预期，通过降低后代的血压变异性，这种“真实”血压将显示出更强的同胞间相关性，并且它将与在临床环境中测量的父母血压更好地相关。在本特库姆塞研究中，使用自我报告的家庭血压和诊所血压读数计算兄弟姐妹之间的相关系数。在380名兄弟姐妹（平均年龄31.4岁）中，家庭读数的相关系数与办公室读数的相关系数相同（家庭，r = 0.23，p小于0.01;办公室，r = 0.24，p小于0.01）。当将后代诊所BP读数与父母的存档BP数据进行比较时，后代诊所和父母诊所BP读数之间的相关性（r = 0.24，p小于0.05）强于后代家庭BP读数与父母诊所BP读数之间的相关性（r = 0.17，p小于0.05）。（250字处删节）
Blood pressure (BP) readings from a single clinic visit are often used in population studies investigating the genetic basis of BP. We examined first-degree relatives in the Tecumseh Blood Pressure study to compare heritability estimates of BP readings obtained in the clinic-office setting (the average of two seated readings) with self-reported home BP readings (the average of 14 readings) taken over a 1-week period. The hypothesis tested was that repeated BP readings obtained in the home over the 1-week period would have fewer artifacts (i.e., environmentally induced variability in BP) and thus would better estimate the true "basal" BP that, in turn, would improve heritability estimates. We and others assume that the true basal BP level is heritable. We therefore expected that this "true" BP, by reducing BP variability of offspring, would show a stronger between-sibling correlation and that it would correlate better to parental BP as measured in a clinic setting. Correlation coefficients were calculated between siblings in the present Tecumseh study using self-reported home BP and clinic BP readings. Among 380 siblings (average age, 31.4 years), correlation coefficients for the home readings were of the same magnitude as for office readings (home, r = 0.23, p less than 0.01; office, r = 0.24, p less than 0.01). When offspring clinic BP readings were compared with archived BP data on parents, the correlation between offspring clinic and parental clinic BP readings was stronger (r = 0.24, p less than 0.05) than the correlation of offspring home BP readings to parental clinic BP readings (r = 0.17, p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)