Exercise-Induced Neuroprotection of the Nigrostriatal Dopamine System in Parkinson's Disease.
Exercise-Induced Neuroprotection of the Nigrostriatal Dopamine System in Parkinson's Disease.
复制标题
运动诱导的帕金森病黑质纹状体多巴胺系统的神经保护
DOI：
10.3389/fnagi.2017.00358
复制
发表时间：
2017
影响因子：
4.8
通讯作者：
Zhou FM
中科院分区：
文献类型：
--
作者：
Hou L;Chen W;Liu X;Qiao D;Zhou FM
流行病学研究表明，体力活动和运动可以降低发生帕金森病（PD）的风险，临床观察表明，体育锻炼可以减轻PD患者的运动症状。在实验动物中，一个深刻的观察是，适当的时间，持续时间和强度的运动可以减少动物PD模型中黑质纹状体多巴胺（DA）系统的毒素诱导的病变，尽管也有负面结果的报道，可能是由于不适当的时间和强度的运动方案。运动还可以最小化DA去神经诱导的中型多刺神经元（MSN）树突萎缩和其他异常，如皮质纹状体突触扩大和异常MSN兴奋性和尖峰活动。总之，流行病学研究、临床观察和动物研究表明，适当剂量的体力活动和运动不仅可以降低脆弱人群发生PD的风险，而且还可以通过潜在地保护残留的DA神经元或直接恢复功能障碍的皮质基底神经节运动控制回路，使PD患者受益。并且这些益处可以通过运动触发的内源性神经保护分子如神经营养因子的产生来介导。因此，运动是一种普遍可用的，无副作用的药物，应作为预防措施开给弱势群体，并作为治疗的一部分给PD患者。未来的研究需要建立标准化的运动方案，可以可靠地诱导DA神经元保护，从而能够描绘潜在的细胞和分子机制，从而可以最大限度地提高运动诱导的神经保护和神经恢复在动物PD模型，并最终在PD患者。
Epidemiological studies indicate that physical activity and exercise may reduce the risk of developing Parkinson's disease (PD), and clinical observations suggest that physical exercise can reduce the motor symptoms in PD patients. In experimental animals, a profound observation is that exercise of appropriate timing, duration, and intensity can reduce toxin-induced lesion of the nigrostriatal dopamine (DA) system in animal PD models, although negative results have also been reported, potentially due to inappropriate timing and intensity of the exercise regimen. Exercise may also minimize DA denervation-induced medium spiny neuron (MSN) dendritic atrophy and other abnormalities such as enlarged corticostriatal synapse and abnormal MSN excitability and spiking activity. Taken together, epidemiological studies, clinical observations, and animal research indicate that appropriately dosed physical activity and exercise may not only reduce the risk of developing PD in vulnerable populations but also benefit PD patients by potentially protecting the residual DA neurons or directly restoring the dysfunctional cortico-basal ganglia motor control circuit, and these benefits may be mediated by exercise-triggered production of endogenous neuroprotective molecules such as neurotrophic factors. Thus, exercise is a universally available, side effect-free medicine that should be prescribed to vulnerable populations as a preventive measure and to PD patients as a component of treatment. Future research needs to establish standardized exercise protocols that can reliably induce DA neuron protection, enabling the delineation of the underlying cellular and molecular mechanisms that in turn can maximize exercise-induced neuroprotection and neurorestoration in animal PD models and eventually in PD patients.
登录
查看更多内容
影响因子：
5.3
作者：
Baydyuk, Maryna;Nguyen, Madeline T.;Xu, Baoji
通讯作者：
Xu, Baoji
影响因子：
5
作者：
Arnold JC;Salvatore MF
通讯作者：
Salvatore MF
DOI：
10.1073/pnas.1004744108
发表时间：
2011-01-25
影响因子：
11.1
作者：
Baydyuk, Maryna;Russell, Theron;Xu, Baoji
通讯作者：
Xu, Baoji
影响因子：
5.3
作者：
Baydyuk M;Xu B
通讯作者：
Xu B
影响因子：
3.7
作者：
Aguiar, Aderbal S., Jr.;Lopes, Samantha C.;Prediger, Rui D.
通讯作者：
Prediger, Rui D.