Sleep deprivation prevents stimulation-induced increases of levels of P-CREB and BDNF: Protection by caffeine
Sleep deprivation prevents stimulation-induced increases of levels of P-CREB and BDNF: Protection by caffeine
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DOI：
10.1016/j.mcn.2011.02.006
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发表时间：
2011-04-01
影响因子：
3.5
通讯作者：
Alkadhi, Karim A.
中科院分区：
文献类型：
--
作者：
Alhaider, Ibrahim A.;Aleisa, Abdulaziz M.;Alkadhi, Karim A.
众所周知，咖啡因和睡眠剥夺对学习和记忆有相反的影响;因此，本研究旨在确定慢性（4周）咖啡因治疗（饮用水中0.3 g/l）对与24 h睡眠剥夺相关的长期记忆缺陷的影响。使用改良的多平台方法剥夺动物的睡眠。结果表明，慢性咖啡因治疗防止损害的长期记忆，在径向臂水迷宫任务和正常化L-LTP在CA 1区的睡眠剥夺麻醉大鼠的性能测量。睡眠剥夺阻止了高频刺激诱导的磷酸化cAMP反应元件结合蛋白（P-CREB）和脑源性神经营养因子（BDNF）水平的增加，这在晚期长时程增强（L-LTP）的表达过程中观察到。然而，慢性咖啡因治疗阻止了睡眠剥夺对P-CREB和BDNF刺激水平的影响。结果表明，慢性咖啡因治疗可能通过保护P-CREB和BDNF的水平来保护睡眠剥夺的大脑。(C)2011 Elsevier Inc. All rights reserved.
It is well known that caffeine and sleep deprivation have opposing effects on learning and memory; therefore, this study was undertaken to determine the effects of chronic (4 wks) caffeine treatment (0.3 g/l in drinking water) on long-term memory deficit associated with 24 h sleep deprivation. Animals were sleep deprived using the modified multiple platform method. The results showed that chronic caffeine treatment prevented the impairment of long-term memory as measured by performance in the radial arm water maze task and normalized L-LTP in area CA1 of the hippocampi of sleep-deprived anesthetized rats. Sleep deprivation prevents the high frequency stimulation-induced increases in the levels of phosphorylated-cAMP response element binding protein (P-CREB) and brain-derived neurotrophic factor (BDNF) seen during the expression of late phase long-term potentiation (L-LTP). However, chronic caffeine treatment prevented the effect of sleep-deprivation on the stimulated levels of P-CREB and BDNF. The results suggest that chronic caffeine treatment may protect the sleep-deprived brain probably by preserving the levels of P-CREB and BDNF. (C) 2011 Elsevier Inc. All rights reserved.